肝细胞癌的免疫疗法:最近的进展和新的策略
Jiarui Li1, Shihai Xuan2, Peng Dong3
1Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.
Frontiers in immunology
|May 26, 2023
概括
肝细胞癌 (HCC) 免疫疗法显示出前景,免疫检查点抑制剂 (ICI) 和其他治疗方法的组合可以改善抗瘤免疫力. 像采用细胞疗法 (ACT) 这样的新方法为个性化HCC治疗方案提供了新的希望.
科学领域:
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
- 癌症研究 癌症研究
背景情况:
- 肝细胞癌 (HCC) 由于其高发病率和死亡率而构成重大全球健康挑战.
- 瘤中瘤微环境是复杂的,涉及各种免疫细胞,细胞因子和瘤信号通路之间的相互作用.
- 对单剂免疫检查点抑制剂 (ICI) 的HCC有限的反应性需要探索替代疗法和组合疗法.
研究的目的:
- 审查当前的情况和免疫疗法在治疗肝细胞癌 (HCC) 中的作用.
- 探索将免疫疗法与HCC的其他治疗方式结合在一起的潜力.
- 突出新兴的免疫治疗策略及其对个性化HCC治疗的潜力.
主要方法:
- 对HCC的免疫治疗现有文献的审查.
- 分析HCC免疫微环境的组成和动态.
- 评估组合疗法,包括放射治疗,化疗,抗血管原剂和ICI.
- 评估新型免疫疗法,如采用细胞疗法 (ACT),癌症疫苗和基于细胞因子的治疗方法.
主要成果:
- 免疫疗法,特别是免疫检查点抑制剂 (ICI),是提高HCC抗瘤免疫力的关键研究领域.
- 涉及放射治疗,化疗,抗血管原剂和ICI的组合策略显示出解决HCC未满足的医疗需求的潜力.
- 新兴的免疫疗法,如ACT,癌症疫苗和细胞因子,在改善瘤细胞根除方面表现出令人鼓舞的有效性.
结论:
- 免疫疗法具有显著的潜力,可以改善肝细胞癌 (HCC) 的治疗结果.
- 组合疗法和新型免疫治疗方法对于克服单一疗法的局限性至关重要.
- 对个性化治疗方案的进一步研究对于优化HCC患者免疫疗法的有效性至关重要.
更多相关视频
11:08Advances in Human Induced Pluripotent Stem Cell-Derived Chimeric Antigen Receptor-Expressing Natural Killer Cells
Published on: February 14, 2025
891
12:24A Three-Dimensional Spheroid Model to Investigate the Tumor-Stromal Interaction in Hepatocellular Carcinoma
Published on: September 30, 2021
5.3K
相关概念视频
Tumor Immunotherapy
584
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
584
Cancer Therapies
7.8K
Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
7.8K
Targeted Cancer Therapies
7.7K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
There are several types of targeted therapies against...
7.7K
Cancer Vaccines
447
Cancer treatment vaccines are a rapidly evolving field that offers a promising approach to immunotherapy. Unlike traditional vaccines that prevent diseases, cancer treatment vaccines are designed to treat existing cancers by stimulating the immune system to recognize and attack cancer cells.
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
447
Combination Therapies and Personalized Medicine
5.0K
Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
5.0K
