解读瘤免疫微环境的细胞对细胞的解读
M Nabhan1, D Egan1, M Kreileder1
1Systems Biology Ireland, School of Medicine, University College Dublin, Belfield, Ireland.
Immuno-oncology technology
|May 26, 2023
概括
免疫检查点抑制剂 (ICI) 在癌症治疗中表现有前途,但可变的反应率突显了对生物标志物的需求. 瘤微环境 (TME) 显著影响ICI的疗效和耐药性.
科学领域:
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
- 癌症生物学 癌症生物学
背景情况:
- 免疫检查点抑制剂 (ICI) 已经改变了癌症治疗,在一些患者中提供了持久的反应.
- 然而,针对不同类型的癌症,ICI的反应率在不同类型的癌症中存在显著差异,因此需要识别预测性生物标志物.
- 瘤微环境 (TME) 在调解对ICI的反应和抵抗方面发挥着关键作用.
研究的目的:
- 审查塑造TME的模式,包括代谢因素,缺氧和与癌症相关的纤维细胞.
- 讨论剖析TME复杂性的先进技术,如单细胞RNA测序,空间转录组学和空间蛋白质组学.
- 突出从多模态TME分析中得出的临床相关发现.
主要方法:
- 对TME组成及其对ICI治疗的影响现有文献的综述.
- 专注于单细胞RNA测序 (scRNA-seq) 进行细胞异质化.
- 空间转录和蛋白质组的整合用于空间上下文.
主要成果:
- 转基因细胞是一个复杂的生态系统,具有动态的细胞相互作用和环境影响 (新陈代谢,缺氧,纤维细胞).
- 多模式分析为TME组成及其对ICI结果的影响提供了前所未有的解决方案.
- 这些先进的技术正在为ICI反应和抵抗机制提供临床相关的见解.
结论:
- 了解TME对于提高ICI治疗疗效至关重要.
- 先进的单细胞和空间技术是剖析TME复杂性的强大工具.
- 来自TME分析的生物标志物有望预测和增强患者对ICI的反应.
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