脂肪乳液给药对末期肺癌患者血液凝结的作用
Takaki Kanie1, Akihiko Futamura2, Tomohiro Mizuno1
1Department of Pharmacy, Fujita Health University Hospital, Toyoake, Aichi, Japan.
Fujita medical journal
|May 26, 2023
概括
在末期肺癌患者中,脂肪乳液的使用没有改变血液凝固. 这项回顾性研究表明,脂肪乳液可以安全地用于这个患者群体,没有观察到新的血栓形成病例.
科学领域:
- 在瘤学瘤学.
- 血液学 血液学 血液学
- 抚慰性护理是一种缓解性护理.
背景情况:
- 患有癌症,特别是肺癌的患者面临高血栓形成的风险.
- 在血栓形成时,Intralipos 20%是禁忌的,而在晚期癌症中,其安全性仍在争论中.
研究的目的:
- 研究脂肪乳液给药对末期肺癌患者血液凝固的影响.
- 评估脂肪乳液在高风险人群中使用的安全性.
主要方法:
- 对213名末期肺癌患者进行了回顾性观察性研究 (2016年1月 - 2019年12月).
- 脂肪乳液注射前和注射后一个月的血液凝固概况 (PT-INR,APTT) 的比较.
- 包括139名接受脂肪乳液的患者和74名对照患者.
主要成果:
- 在脂肪乳液注射后,没有观察到前列血时间-国际正常化比率 (PT-INR) 或激活的部分血栓形成时间 (APTT) 的显著变化.
- 脂肪乳液组 (n=27) 显示稳定的PT-INR (1.17±0.26至1.16±0.12) 和APTT (30.5±5.0秒至31.2±4.2秒).
- 不给药组 (n=6) 在PT-INR (1.44±0.43至1.28±0.18) 和APTT (30.6±5.2秒至33.0±7.5秒) 中也没有显著变化.
结论:
- 在末期肺癌患者中,脂肪乳液的使用没有影响血液凝固参数 (PT-INR,APTT).
- 没有报告新的血栓形成事件,这表明在这个队列中安全使用脂肪乳液.
- 这些发现表明,脂肪乳液可以安全地给终末期肺癌患者服用,而不会增加血栓形成的风险.
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