与骨髓溶解相关的急性损伤
Mohanasundaram Subashri1, S Sujit1, K Thirumalvalavan1
1Department of Nephrology, Government Stanley Medical College and Hospital, Chennai, Tamil Nadu, India.
Indian journal of nephrology
|May 26, 2023
概括
轮骨髓溶解引起的急性损伤 (AKI) 是一种严重的并发症. 这项研究发现创伤性和非创伤性原因均有贡献,大多数患者从AKI中恢复过来,强迫性性尿液有助于非创伤性病例的恢复.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 内部医学 内部医学
- 毒理学 毒理学 毒理学
背景情况:
- 急性损伤 (AKI) 是拉布多米解的严重并发症.
- 拉布多溶解涉及肌肉分解,释放肌球蛋白,这可能会损害脏.
- 了解拉布地质溶解诱导的AKI的原因和结果对于患者的管理至关重要.
研究的目的:
- 分析患者的病因学,临床表现,实验室发现和结局,这些患者的活检证明了色素诱导脏病.
- 为了确定风险因素和有效的治疗方法与拉布地质溶解相关的AKI.
主要方法:
- 从2017年1月到2019年9月进行了一项前性观察研究.
- 收集的数据包括患者病史,临床检查,实验室结果和脏活检结果.
- 记录了26名患者的结果和治疗方法.
主要成果:
- 患者的平均年龄为34.81岁,肌素,CPK和LDH水平升高.
- 鉴定出了创伤性 (46%) 和非创伤性 (54%) 的拉布多米解的原因.
- 大多数患者需要脏替代疗法 (血液透析或腹腔透析);15.4%死亡,7.7%进展为慢性脏疾病.
结论:
- 与固醇溶解相关的AKI是功能衰竭的重要原因.
- 创伤性和非创伤性病因都有同等的贡献.
- 强迫性尿液在治疗非创伤性狂犬病诱导的AKI方面表现有前途,大多数患者康复.
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