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糖尿病足部感染中的肠球菌:流行率,临床特征和结果
Ofer Perzon1,2, Avivit Cahn3,2, Yechiel N Gellman4,2
1Department of Internal Medicine, Hadassah Hebrew University Medical Center, Ein Kerem, Jerusalem, Israel.
肠球菌在糖尿病足部感染 (DFI) 中很常见,导致更多的截肢和更长的住院时间. 针对肠球菌的向抗生素治疗可能会减少重大截肢,这需要进一步研究.
科学领域:
- 传染性疾病 传染性疾病
- 足部医学是一门专业.
- 抗微生物药物管理委员会
背景情况:
- 糖尿病足部感染 (DFI) 往往是多微生物的,肠球菌的具体作用尚不清楚.
- 治疗肠球菌DFI的患病率,致病性和影响需要进一步调查.
研究的目的:
- 确定DFI中肠球菌的流行率和临床意义.
- 评估针对性抗肠球菌治疗对患者结局的影响.
主要方法:
- 从537名DFI患者 (2014-2019) 的人口统计,临床和结局数据的回顾性分析.
- 主要结局:医院死亡或重大截肢的组合.
- 二次结果:任何截肢,重大截肢,停留时间,以及1年死亡率/重大截肢率.
主要成果:
- 在35%的DFI病例中隔离了肠球菌,与较高的外周血管疾病,C反应蛋白和瓦格纳分数相关.
- 受肠球菌感染的患者的截肢率更高 (72.3%对50.1%),住院时间更长 (22.5天对17天).
- 适当的抗肠球菌抗生素显示了减少主要截肢的趋势 (20.4%对34.1%),但住院时间更长.
结论:
- 肠球菌在DFI中普遍存在,并且与截肢率和住院时间的增加有关.
- 追溯数据表明,适当的抗肠球菌治疗可能会降低主要截肢率.
- 需要进行前性研究来验证有关肠球菌DFI治疗的这些发现.
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