慢波睡眠期间心率变化与中央自主网络的功能连接有关
Shawn D X Kong1,2,3, Christopher J Gordon4,5, Camilla M Hoyos1,2,3,4
1Healthy Brain Ageing Program, Brain and Mind Centre, University of Sydney, Camperdown, NSW 2050, Australia.
Brain communications
|May 26, 2023
概括
深度睡眠期间心率变化减少与老年人患痴呆风险的大脑连接有关. 这表明与睡眠有关的脑心相互作用可能是神经退行性疾病进展的关键.
科学领域:
- 神经科学是一个神经科学.
- 心脏病学 心脏病学
- 老年学是一门学科.
背景情况:
- 减少心率变化 (HRV) 是神经退行性疾病中自主功能障碍的早期指标.
- 睡眠期间的自主功能障碍,这是研究脑心相互作用的理想状态,在痴呆风险方面仍未得到充分研究.
- 中央自主网络 (CAN) 在调节自主功能方面发挥着至关重要的作用.
研究的目的:
- 调查夜间睡眠,特别是慢波睡眠中的HRV与CAN功能连接之间的关联.
- 为了检查老年人中这些关系,确定他们有痴呆风险.
主要方法:
- 休息状态功能性磁共振成像 (fMRI) 和一夜间的多睡眠成像在78名患有痴呆症风险的老年人身上进行.
- 提取高频率HRV以测量不同睡眠阶段的副交感活动.
- 一般线性模型评估了CAN功能连接和HRV之间的关系.
主要成果:
- 慢波睡眠期间高频HRV的增加与核心CAN区域 (右前胰岛,后中皮层) 的功能连接性更强相关.
- 慢波睡眠期间的副交感活动也与右桃体和体亚核之间增强的连接有关.
- 没有发现HRV和CAN连接在睡眠开始后的觉醒或REM睡眠期间之间存在显著的关联.
结论:
- 慢波睡眠期间的副交感神经系统调节与老年人痴呆风险中CAN内的特定功能连接模式有独特的关联.
- 功能障碍的大脑与心脏的相互作用可能在慢波睡眠期间表现出来,这是记忆和废物清除的关键时期.
- 需要进一步的研究来澄清在CAN中HRV和神经退行症之间的因果关系.
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