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氧化应激,还原应激和抗氧化剂在血管病原和衰老中的作用
Mitko Mladenov1, Lubomir Lubomirov2, Olaf Grisk2
1Faculty of Natural Sciences and Mathematics, Institute of Biology, "Ss. Cyril and Methodius" University, P.O. Box 162, 1000 Skopje, North Macedonia.
Antioxidants (Basel, Switzerland)
|May 27, 2023
概括
这篇评论探讨了抗氧化化合物和激素如虹膜素和黑激素如何维持氧化还原平衡,影响健康,衰老和疾病. 它强调了亲氧化剂的风险及其与炎症和器官特异性压力的联系.
科学领域:
- 生物化学和分子生物学
- 营养科学 营养科学
- 毒理学 毒理学 毒理学
背景情况:
- 细胞氧化还原状态对健康至关重要,与疾病,衰老和炎症相关的偏差.
- 氧化和还原应激显著影响细胞功能和平衡.
- 抗氧化剂食品成分和荷尔蒙在维持氧化还原平衡方面发挥着关键作用.
研究的目的:
- 审查调节健康,疾病和衰老中的氧化还原状态的机制.
- 探索可以抵消氧化和还原应激的信号通路.
- 讨论抗氧化剂,激素和毒素在氧化还原平衡中的作用.
主要方法:
- 对氧化还原生物学科学研究的文献综述.
- 对参与氧化应激反应的信号通路的分析.
- 检查饮食成分和环境毒素对细胞氧化还原状态的影响.
主要成果:
- 确定了关键的抗氧化化合物 (黄素,多,维生素等). 和激素 (伊丽素,黑激素) 支持氧化还原稳定.
- 与炎症,过敏,衰老和自身免疫性疾病相关的偏离最佳的氧化还原条件.
- 突出了血管,,肝脏和大脑系统中的氧化应激,以及过氧化的信号作用.
- 引入的毒素 (BMAA等) 作为潜在的食物和环境亲氧化剂.
结论:
- 保持最佳的氧化还原平衡对于预防疾病和促进健康衰老至关重要.
- 饮食中的抗氧化剂和特定激素对细胞保护免受氧化还原失衡至关重要.
- 环境的亲氧化剂,包括毒素,通过破坏氧化还原稳定性来构成重大健康风险.
关键词:
在NADPH氧化酶.在 ROS 信号传输中.老化的老化 衰老的老化这是一种抗炎药物.抗过敏的 抗过敏的库尔库明是一种黄素.毒素的使用情况.虹膜是一种虹膜.黑激素是什么意思 黑激素是什么意思线粒体中的线粒体.更多相关视频
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