高和高:芬太尼在健康猪中诱导精神运动副作用
Nora Digranes1, Henning Andreas Haga1, Janicke Nordgreen2
1Department of Companion Animal Clinical Sciences, Faculty of Veterinary Medicine, Norwegian University of Life Sciences, 1430 Ås, Norway.
Animals : an open access journal from MDPI
|May 27, 2023
概括
芬太尼改变了猪的行为,导致运动变化并抑制正常活动. 血清激素通路可能会影响这些芬太尼的作用,影响疼痛评估.
科学领域:
- 兽医行为 兽医行为
- 动物药理学动物药理学
背景情况:
- 芬太尼的止痛特性是众所周知的,但其行为效应和潜在的血清激素影响仍然不清楚.
- 了解这些影响对于准确评估研究动物的疼痛至关重要.
研究的目的:
- 调查芬太尼在猪身上对行为和运动的影响.
- 探索使用 ketanserin 在芬太尼的行为效应中所起的 serotonergic 通路的作用.
主要方法:
- 这是一项对14头猪进行的随机,盲目,前性研究.
- 芬太尼尔静脉注射,其次是基坦林 (血清抗剂) 或盐水.
- 行为分析包括自动距离跟踪和特定行为手动评分.
主要成果:
- 芬太尼显著增加了移动的距离,并诱导了重复行为,同时抑制了休息和玩.
- 经过芬太尼后观察到硬的步态模式, ketanserin显著减少.
- 芬太尼的作用表明涉及到血清的传播.
结论:
- 芬太尼在猪中诱导了明显的运动和行为变化.
- 血清能路径似乎在某些芬太尼观察到的效果中起作用.
- 芬太尼的精神运动副作用可能会混猪手术后疼痛评估.
关键词:
行为行为行为行为.芬太尼 (Fentanyl) 是一种药物.凯坦塞林是什么 凯坦塞林是什么机车运动 机车运动猪猪猪猪猪猪猪猪猪猪猪猪猪猪猪猪猪猪猪猪猪猪猪猪猪猪猪猪猪猪猪猪猪血清胺 (serotonin) 是一种神经元.更多相关视频
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