在COVID-19后的大脑体积变化与基于人工智能的MRI体积测量的健康对照相比
Zeynep Bendella1, Catherine Nichols Widmann2,3, Julian Philipp Layer4,5
1Department of Neuroradiology, University Hospital Bonn, Rheinische Friedrich-Wilhelms-Universität Bonn, Venusberg-Campus 1, 53127 Bonn, Germany.
Diagnostics (Basel, Switzerland)
|May 27, 2023
概括
COVID-19 感染会导致大脑缩,特别是在严重的病例中. 这种大脑退化会影响前额-双脑区域和右丘脑,影响康复后的认知功能.
科学领域:
- 神经科学是一个神经科学.
- 传染性疾病 传染性疾病
- 医疗成像医学成像
背景情况:
- 关于与COVID-19严重程度相关的大脑体积变化的数据有限.
- COVID-19严重程度与大脑完整性之间的相关性尚不清楚.
研究的目的:
- 评估COVID-19对轻度和重度病例与对照病例的大脑体积的影响.
- 利用基于人工智能 (AI) 的MRI体积来量化大脑变化.
主要方法:
- 预计将155名参与者纳入轻度COVID-19,严重COVID-19和健康的对照组.
- 标准化的大脑MRI协议与基于AI的体积测量 (mdbrain软件) 在3D T1加权的MPRAGE序列上.
- 多变量分析以确定COVID-19严重程度和临床因素对大脑体积的影响.
主要成果:
- 在两组之间观察到大脑体积和百分位数的统计学上显著差异.
- 在COVID-19患者中,体积显著减少,随着疾病的严重程度而增加 (严重>轻微>控制).
- 受影响的区域包括 supratentorial灰质,额叶和叶,以及右丘脑,独立于ICU治疗.
结论:
- 与对照组相比,在康复的COVID-19患者中检测到新皮层脑退化.
- 大脑缩随着更大的初始COVID-19严重程度而恶化,影响特定的大脑区域.
- 研究结果表明,SARS-CoV-2感染和大脑缩之间存在直接联系,这对临床管理和康复有影响.
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