口腔状细胞癌患者的预后和诺莫格拉姆预测:一个队列研究
Xin-Yuan Zhang1, Shang Xie1, Dian-Can Wang1
1Department of Oral and Maxillofacial Surgery, Peking University School and Hospital of Stomatology & National Center of Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Research Center of Oral Biomaterials and Digital Medical Devices, Beijing 100081, China.
Diagnostics (Basel, Switzerland)
|May 27, 2023
概括
这项研究开发了一种新的诺莫格拉姆模型,用于预测口腔状细胞癌 (OSCC) 患者手术后的生存率. 该模型结合了性别和BMI等因素,比TNM分期提供了更好的预后准确性.
科学领域:
- 在瘤学瘤学.
- 手术病理学手术病理学
- 生物统计学 生物统计学
背景情况:
- TNM分期系统是口腔状细胞癌 (OSCC) 预后的标准.
- 在具有相同TNM阶段的OSCC患者中存在显著的生存变异性.
研究的目的:
- 调查术后OSCC的预后因素.
- 开发和验证OSCC患者的诺莫格拉姆生存预测模型.
主要方法:
- 对432名OSCC患者的手术记录进行了回顾性审查.
- 考克斯回归分析以确定显著的预后变量.
- 诺莫格拉姆模型构建和验证整体存活率 (OS).
主要成果:
- 使用性别,BMI,OPMD,疼痛评分,SCC等级和N阶段开发了一个名录模型.
- 该模型表现出良好的预测稳定性,C指数值为0.782 (3年) 和0.770 (5年).
结论:
- 这种新型的诺莫格拉姆模型显示了提高术后OSCC存活率的临床预测的潜力.
- 这种工具可能有助于对OSCC患者进行更个性化的预后评估.
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