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曼尼托尔挑战评估喘儿童的治疗反应:一种干预性队列研究
Nikolaos Karantaglis1, Fotios Kirvassilis1, Elpis Hatziagorou1
1Pediatric Pulmonology and Cystic Fibrosis Unit, 3rd Pediatric Department, Aristotle University of Thessaloniki, Hippokration General Hospital of Thessaloniki, Konstantinoupoleos Str. 49, 54642 Thessaloniki, Greece.
Children (Basel, Switzerland)
|May 27, 2023
概括
曼尼托尔挑战有效地监测儿童的喘. 经过三个月的喘预防后,支气管过敏反应得到改善,这表明治疗的有效性.
科学领域:
- 儿科肺病学 儿科肺病学
- 呼吸系统医学 呼吸系统医学
- 临床过敏 临床过敏
背景情况:
- 支气管过敏反应 (BHR) 是喘的一个标志.
- 曼尼托尔挑战测试用于评估喘患者的BHR.
- 关于曼尼托尔挑战作为儿科喘监测工具的数据有限.
研究的目的:
- 评估曼尼托尔挑战作为儿童喘控制的监测工具.
- 在喘预防三个月后评估BHR对曼尼托尔的变化.
- 为了将曼尼托尔挑战结果与喘症状存在相关联.
主要方法:
- 对23名未接受过治疗的喘儿童 (4至16岁) 的前性队列研究.
- 在基线和经过3个月的布德索尼德±形式醇治疗后进行的曼尼托尔挑战.
- 评估曼尼托尔 (PD15) 的挑剂量导致FEV1下降15%,并与夜间和运动诱导的喘症状相关联.
主要成果:
- 在三个月的喘预防后,PD15显著增加 (p=0.04),表明BHR减少.
- 较低的PD15值与夜间喘症状相关 (p=0.03).
- 在PD15值和运动诱导的喘症状之间没有发现显著的关联 (p=0.73).
结论:
- 曼尼托尔挑战显示了作为儿童喘监测工具的潜力.
- 它可以反映在接受预防性喘治疗的儿童的治疗反应.
- 曼尼托尔挑战结果与夜间喘症状相关,这表明它在评估喘控制中的有用性.
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