发烧性尿路感染的婴儿尿中肝素水平升高和低血症:一项前性队列研究
Yu-Chen Hsu1, Hsin-Chun Huang1,2, Kuo-Su Tang1
1Department of Pediatrics, College of Medicine, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University, Kaohsiung 83301, Taiwan.
Children (Basel, Switzerland)
|May 27, 2023
概括
婴儿发烧性尿路感染 (UTI) 会提高尿肝素-肌素比率,这种标记物在抗生素治疗后显著下降,特别是在大肠杆菌感染时.
科学领域:
- 儿科 儿科 儿科
- 传染性疾病 传染性疾病
- 腎臟病學 (nephrology) 是一種醫學.
背景情况:
- 发烧性尿路感染 (UTI) 在婴儿中很常见.
- 肝素在铁的平衡和炎症中起作用.
- 作为儿科感染的生物标志物,尿肝素-肌素比率正在研究中.
研究的目的:
- 为了研究发烧性尿路感染的婴儿血清和尿路肝素水平的动力学.
- 在感染和治疗期间,将肝素水平与贫血相关的参数相关联.
- 为了比较大肠杆菌和非大肠杆菌尿路感染之间的发现.
主要方法:
- 对1-4个月龄的发烧婴儿患有尿路感染的前性研究.
- 分类为大肠杆菌和非大肠杆菌的尿路感染群.
- 在入院和抗生素治疗后收集血清肝素,铁形状和尿液肝素-肌素比率.
主要成果:
- 发烧性尿路感染的婴儿在入院时显示血清铁含量降低,尿液肝素-肌素比率升高.
- 尿液中的肝素-肌素比率是尿路感染的显著预测因素 (OR 2.01).
- 经过3天的抗生素治疗后,血红蛋白和尿肝素-肌素比率显著下降,特别是在大肠杆菌尿路感染中.
结论:
- 在婴儿的急性发烧性尿路感染期间,尿液中的肝素-肌素比率升高.
- 在抗生素治疗后,这种比率显著下降,表明炎症已消失.
- 在E. coli和非E. coli的尿路感染中,尿路肝素-肌素比率对治疗的反应不同.
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