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为儿科翻译精确健康:一个范围审查
Mathushan Subasri1, Celine Cressman1, Danielle Arje1,2
1Child Health Evaluative Sciences Program, The Hospital for Sick Children Research Institute, Toronto, ON M5G 1X8, Canada.
精确的儿童健康需要量身定制的方法,因为独特的儿科生理学. 本次审查确定了在儿童中实施精确健康干预措施的关键挑战和解决方案.
科学领域:
- 儿科的精确卫生保健
- 翻译科学是翻译的科学.
- 基于证据的医学是基于证据的医学.
背景情况:
- 精密健康利用遗传差异个性化护理,改善某些群体的结果.
- 更广泛的实施在证据开发,评估和整合方面面临障碍.
- 现有的方法往往忽视了儿童独特的生理学和社会生物学.
研究的目的:
- 审查和综合有关证据开发,评估,优先考虑和实施精确儿童健康的文献.
- 确定将精准健康转化为儿科实践的挑战和解决方案.
- 突出在精密健康研究中对儿童的独特考虑.
主要方法:
- 文学范围审查. 文学范围审查.
- 在PubMed,Scopus,Web of Science和Embase进行的搜索.
- 纳入标准集中在儿科,精密健康和转化途径.
主要成果:
- 74篇文章确定了儿科精确健康干预的挑战和解决方案.
- 儿童的独特属性显著影响研究设计.
- 价值评估的关键主题包括临床益处,成本效益,利益相关者的价值观和道德.
结论:
- 应对挑战需要国际数据网络和指南.
- 重新思考价值评估方法至关重要.
- 扩大利益相关者支持对于有效实施精确儿童健康至关重要.
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