分支链氨基酸与末期肝病患者的身体表现有关
Maria Camila Trillos-Almanza1, Hanna Wessel1, Magnolia Martínez-Aguilar1
1Department of Gastroenterology and Hepatology, University Medical Center Groningen, University of Groningen, P.O. Box 30.001, 9700RB Groningen, The Netherlands.
Biomolecules
|May 27, 2023
概括
循环分支链氨基酸 (BCAA) 减少与更严重的末期肝病 (ESLD) 和较差的肌肉功能有关. 这些发现表明,BCAA水平可能作为肝病病期的预后标志物.
科学领域:
- 生物化学 生物化学
- 肝病学 肝病学是一种肝病学.
- 老年病的医生 老年病的医生
背景情况:
- 循环分支链氨基酸 (BCAA) 的减少是末期肝病 (ESLD) 的特征.
- 这些氨基酸的变化与萨尔科佩尼亚,肝脏脑病变以及患者预后不佳有关.
- 了解BCAA水平与疾病严重程度之间的关系对于患者管理至关重要.
研究的目的:
- 调查血BCAA水平与ESLD严重程度之间的关联.
- 检查肝移植候选人的BCAA水平与身体表现之间的相关性.
- 探索BCAA作为ESLD预后生物标志物的潜力.
主要方法:
- 对来自TransplantLines肝移植子组的92名患者的横截面分析.
- 用核磁共振光谱学量化的血BCAA水平.
- 身体表现通过手握强度,4米步行,坐立,计时上升和上升,平衡测试和脆弱度量表来评估.
主要成果:
- 查尔德-普格-图尔科特分类在最低的BCAA三位数中明显高于最高的.
- 在总BCAA水平和坐立测试时间 (r = -0.352,p < 0.05) 之间观察到逆相关性.
- 在总BCAA水平和定时升级和启动测试时间 (r = -0.472,p < 0.01) 之间观察到逆相关性.
结论:
- 较低的循环BCAA水平与ESLD严重程度的增加显著相关.
- 降低的BCAA水平与肌肉功能受损相关,包括较慢的坐立和时间上升和上升的表现.
- 循环中的BCAA可以作为一个有价值的预后标记,用于分期肝病的严重程度.
关键词:
慢性肝脏疾病 慢性肝脏疾病基本氨基酸是必需的氨基酸.脆弱 脆弱 脆弱 脆弱 脆弱功能性表现的功能性表现.肝硬化是肝硬化的一种疾病.肝脏脑病变 - 肝脏脑病变 - 肝脏脑病变肝移植 肝移植 肝移植磁共振光谱学 磁共振光谱学肌肉的发展 肌肉的发展 肌肉的发展这种类型的麻症是sarcopenia.更多相关视频
08:04Isolation of Primary Mouse Hepatocytes for Nascent Protein Synthesis Analysis by Non-radioactive L-azidohomoalanine Labeling Method
Published on: October 23, 2018
19.0K
12:27Technique of Porcine Liver Procurement and Orthotopic Transplantation using an Active Porto-Caval Shunt
Published on: May 7, 2015
16.5K
相关概念视频
01:30Liver Physiology
710
The liver, an essential organ in the human body, performs over 200 vital functions that can be broadly categorized into metabolic, hematological, endocrine regulation, and bile production.
Metabolic Regulation:
The liver is the central organ involved in regulating blood composition. It stabilizes blood glucose levels, maintaining them within the range of 70–110 mg/dL. When these levels drop, the liver breaks down glycogen reserves and releases glucose into the bloodstream. It can...
Metabolic Regulation:
The liver is the central organ involved in regulating blood composition. It stabilizes blood glucose levels, maintaining them within the range of 70–110 mg/dL. When these levels drop, the liver breaks down glycogen reserves and releases glucose into the bloodstream. It can...
710
01:24Liver Regeneration
3.3K
The liver is an important organ in vertebrates that plays an essential role in metabolism. It is also responsible for storing and redistributing nutrients such as carbohydrates, fats, and vitamins in the body. Additionally, the liver releases bile salts which are critical for digesting food and eliminating toxic metabolites from the body.
Cells of Liver
The liver comprises four major types of cells— hepatocytes, stellate, Kupffer, and sinusoidal endothelial cells. The hepatocytes are...
Cells of Liver
The liver comprises four major types of cells— hepatocytes, stellate, Kupffer, and sinusoidal endothelial cells. The hepatocytes are...
3.3K
01:27Exercise and Muscle Performance
1.5K
Exercise induces a range of adaptations in muscle tissue, depending on the type and duration of activity. Such physical training can be broadly categorized into two types: endurance exercises and resistance exercises.
Endurance exercises
Endurance exercises involve running, swimming, or cycling, which require repetitive movements with low force output. When a person engages in endurance exercise, a few noticeable changes occur in their skeletal muscles. For instance, the number of capillaries...
Endurance exercises
Endurance exercises involve running, swimming, or cycling, which require repetitive movements with low force output. When a person engages in endurance exercise, a few noticeable changes occur in their skeletal muscles. For instance, the number of capillaries...
1.5K
01:29Chronic Pancreatitis II: Collaborative Care
117
The management of chronic pancreatitis is multifaceted, involving a comprehensive approach that includes thorough assessment, diagnostic testing, and a variety of management strategies.
Assessment:
Assessment:
117