含有黄素的固体脂质纳米颗粒与不同固体脂质和乳化剂的物理化学和体外消化性能
Yasi Yu1,2, Dechu Chen1,2, Yee Ying Lee3
1JNU-UPM International Joint Laboratory on Plant Oil Processing and Safety, Department of Food Science and Engineering, Jinan University, Guangzhou 510632, China.
Foods (Basel, Switzerland)
|May 27, 2023
概括
中长链二甲基甘油 (MLCD) 脂质矩阵增强黄载固体脂质纳米粒子 (Cur-SLN) 的稳定性和生物可用性. 在Tween 20 (T20) 中,表面活性剂改善了Cur-SLN的消化能力和释放,这表明功能性食品的潜力.
科学领域:
- 纳米技术纳米技术
- 材料科学 材料科学 材料科学
- 食品科学 食品科学 食品科学
背景情况:
- 固体脂质纳米粒子 (SLNs) 是有前途的药物输送系统.
- 黄素 (Cur) 由于溶解度低和新陈代谢快,具有较差的生物利用性.
- 脂质矩阵和表面活性剂的选择显著影响SLN的特性和性能.
研究的目的:
- 研究不同脂质矩阵 (MLCD与TP) 和表面活性剂 (T20,SQ,Rha) 对Cur-SLN特征的影响.
- 评估Cur-SLNs的稳定性,封装效率和体外性能.
- 了解MLCD在通过SLN增强脂性化合物递送中的作用.
主要方法:
- 使用MLCD或甘油三胺酸 (TP) 脂质核和T20,SQ或Rha表面活性剂制备Cur-SLNs.
- 描述SLN的大小,表面电荷,封装效率和稳定性.
- 热分析 (DSC) 和X射线衍射 (XRD) 来评估脂质矩阵结构和多态性.
- 在体外消化性和生物可用性研究.
- 药物释放动力学的数学建模.
主要成果:
- 与TP-SLN相比,基于MLCD的SLN具有较小的粒子大小,较低的表面电荷和更高的存储稳定性.
- 黄素封装效率在87.54-95.32%之间.
- 在Tween 20 (T20) 中,表面活性剂显著提高了Cur-SLN的消化能力和体外生物可用性,以及更快的释放率.
- 在MLCD-SLNs中,多态过渡不那么显著,这有助于它们的稳定性得到改善.
结论:
- MLCD是开发稳定和有效的Cur-SLN的合适脂质矩阵.
- 表面活性剂的选择,特别是T20,极大地影响了Cur的生物可用性和释放动力学.
- 这些发现支持脂质纳米载体的合理设计,以提高功能性食品中脂性化合物的递送.
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