抗脂抗体在急性SARS-CoV-2感染中发生的情况,没有开放性血栓形成
Alina Dima1, Daniela Nicoleta Popescu1, Ruxandra Moroti2,3
1Department of Rheumatology, Colentina Clinical Hospital, 020125 Bucharest, Romania.
Biomedicines
|May 27, 2023
概括
抗脂抗体 (aPLs),特别是狼抗凝剂 (LA),在早期COVID-19中很常见. 在没有先前血栓形成的患者中,LA存在与COVID-19严重程度的增加相关.
科学领域:
- 免疫学 免疫学 免疫学
- 病毒学 病毒学
- 血液学 血液学 血液学
背景情况:
- 抗脂抗体 (aPLs) 与血栓形成有关.
- 在COVID-19严重性中aPLs的作用尚未完全理解,特别是在没有血栓事件的早期感染中.
研究的目的:
- 确定在感染早期阶段住院的COVID-19患者中aPLs的流行率.
- 在没有血栓事件的患者中调查aPLs和COVID-19严重程度 (临床和实验室参数) 之间的相关性.
主要方法:
- 对179名住院COVID-19患者的横截面研究 (2020年4月至2021年5月).
- 排除标准包括先前的免疫疾病,血栓性,长期抗凝药和SARS-CoV-2感染期间的明显血栓症.
- 评估了aPLs的四个标准:狼抗凝剂 (LA),IgM和IgG抗心蛋白抗体 (aCL) 和IgG抗β2糖蛋白I抗体 (aβ2GPI).
主要成果:
- 狼抗凝剂 (LA) 是最常见的aPL,在41.9%的患者中发现.
- 在严重的COVID-19病例中,LA更频繁 (p=0.027).
- 在多变量分析中,只有C反应蛋白 (CRP) 水平与LA阳性相关 (OR 1.008,p=0.042).
结论:
- 狼抗凝剂 (LA) 是COVID-19急性阶段常见的抗脂抗体.
- 在没有明显血栓形成的患者中,LA的存在与COVID-19严重程度的增加有关.
- 进一步的研究可能会探索LA在COVID-19中的病原性作用.
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