查20种精油的神经保护和快速抗抑郁药效果的查
Khoa Nguyen Tran1, Nhi Phuc Khanh Nguyen1, Ly Thi Huong Nguyen1
1Department of Physiology, College of Korean Medicine, Dongguk University, Gyeongju 38066, Republic of Korea.
Biomedicines
|May 27, 2023
概括
研究人员对精油进行了快速抗抑郁作用的选,确定了向谷氨酸受体的化合物. 两种精油,Atractylodes lancea和Chrysanthemum morifolium,在开发快速起作用的抗抑郁药方面表现有前途.
科学领域:
- 神经科学是一个神经科学.
- 药理学 药理学是指药理学的学科.
- 自然产品 化学 化学
背景情况:
- 抑郁症是一种普遍的精神疾病,由于抗抑郁药效果延迟,治疗选择有限.
- 精油是新型治疗剂的潜在来源,其作用更快.
研究的目的:
- 为了选精油的神经保护性质,并确定候选人快速起作用抗抑郁药的发展.
- 研究有希望的精油及其向谷氨酸受体的化合物的作用机制.
主要方法:
- 使用PC12和BV2细胞进行体外查,以评估对皮质激素 (CORT) 和脂多糖 (LPS) 诱导毒性的神经保护作用.
- 在ICR小鼠体内评估,使用尾部悬浮试验 (TST) 和鼻内注射后升高加迷宫 (EPM).
- 从有效的精油中获得的关键化合物的计算分析,以确定它们与谷氨酸受体子单元的亲和力.
主要成果:
- 19种精油表现出对CORT诱导的细胞死亡的神经保护,13种减少了LPS诱导的炎症标志物 (TNF-α,IL-6).
- 六种精油缩短了TST中的不动性,花 (Chrysanthemum morifolium) 和花香 (Myristica fragrans) 也改善了EPM中的性能.
- 四种化合物 (atractylon,α-curcumene,α-farnesene,selina-4(14),7(11) -dien-8-one) 对谷氨酸受体子单元 (GluN1,GluN2B,Glu2A) 呈现出高亲和力,超过了胺的亲和力.
结论:
- 阿特拉提洛德斯兰西亚和克里桑瑟姆莫里福利姆精油显示出开发快速起作用抗抑郁药的巨大潜力.
- 预计已识别的化合物通过与谷氨酸受体的相互作用来调解快速抗抑郁作用.
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