在患有后部和膜炎的患者中存在胸腔洞
Tedi Begaj1, Amy Yuan2, Ines Lains1
1Department of Ophthalmology, Massachusetts Eye and Ear, Harvard Medical School, Boston, MA 02114, USA.
Biomedicines
|May 27, 2023
概括
现在,慢性非传染性脑膜炎 (NIU) 患者中发现了胸腔洞 (CC). 这些洞穴最常见的是后膜炎,特别是多焦点胆管炎,与男性性别相关.
科学领域:
- 眼科医生 眼科 眼科
- 医疗成像医学成像
- 冠状腺疾病 冠状腺疾病
背景情况:
- 胸腔洞穴 (CCs) 是血管异常,以前与与年龄相关的黄斑变性和胸腔病有关.
- 慢性非传染性脑膜炎 (NIU) 患者中CCs的存在和特征在很大程度上仍未得到研究.
研究的目的:
- 调查诊断为患有慢性非传染性紫外炎的患者中胸腔洞的患病率和相关因素.
- 为了确定CC是否是膜炎导致的状腺结构或血管变化的潜在后续.
主要方法:
- 135名NIU患者 (251只眼睛) 的回顾性图表审查.
- 眼科成像包括光学连贯性断层扫描 (OCT) 和内绿色血管扫描 (ICGA) 用于识别CCs.
- 单变量和多变量混合效应物流模型分析了临床/人口因素和CC存在之间的关联.
主要成果:
- 在研究的NIU队列中,CC的总体患病率为10%.
- 仅在患有后膜炎 (10.8%的患病率) 和面膜炎 (7.8%的患病率) 的眼睛中观察到CC.
- 多焦性胆道炎 (MFC) 显示CCs的患病率最高 (40%),男性性别与CCs有显著的关联 (p=0.024).
结论:
- 这项研究是首次报告非传染性脑膜炎患者体内腔洞的存在.
- 这些发现表明,CCs可能会由于紫外线炎引起的胸腔结构或血管变化而发展.
- 与没有CC的眼睛相比,CCs在眼内炎症或胸腔厚度上没有显著差异.
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