对患有上升胸前大动脉动脉瘤患者的向蛋白质组分析
Aphrodite Daskalopoulou1, Sotiria G Giotaki2, Konstantina Toli3
1Laboratory for Experimental Surgery and Surgical Research "N.S. Christeas", Athens Medical School, National and Kapodistrian University of Athens, 115 27 Athens, Greece.
Biomedicines
|May 27, 2023
概括
研究人员确定了C-C动机化学基因连接体5 (CCL5),防御蛋白β1 (HBD1) 和细胞内粘附分子-1 (ICAM1) 作为上升胸前动脉动脉瘤 (ATAA) 的有希望的生物标志物. 这些标志物显示出改善ATAA风险分层和诊断的潜力.
科学领域:
- 心血管研究研究心血管研究
- 生物标志物发现发现
- 蛋白质组学是指蛋白质组学.
背景情况:
- 上升胸前动脉动脉瘤 (ATAA) 缺乏用于早期检测和风险评估的特定临床标志物.
- 确定可靠的生物标志物对于管理患有ATAA发展风险的患者至关重要.
研究的目的:
- 通过针对性蛋白质组分析,识别用于诊断ATAA的新型蛋白质生物标志物.
- 评估这些生物标志物的潜力,在分层的个体有风险的ATAA.
主要方法:
- 针对52名ATAA患者和30名对照患者的血样本进行了向蛋白质组分析.
- 患者根据上升性大动脉直径 (4.0-5.0厘米和>5.0厘米) 进行分组.
- 通过心声学和血管计算机断层扫描 (CT) 扫描来确认诊断.
主要成果:
- 与对照组相比,ATAA患者中CCL5,HBD1,ICAM1,IL8,TNFα和TGFB1的表达显著升高 (p < 0.0001).
- CCL5,HBD1和ICAM1的诊断准确性很高,曲线下的面积 (AUC) 值分别为0.84,0.83和0.83.
- 这三种生物标志物与其他分析的蛋白质相比,表现优越.
结论:
- CCL5,HBD1和ICAM1被确定为ATAA的非常有前途的生物标志物.
- 这些生物标志物具有令人满意的灵敏度和特异性,有助于风险分层和诊断.
- 需要进一步的研究来探索这些生物标志物在ATAA病变发生中的作用.
相关概念视频
01:21Aneurysm II: Clinical Manifestations and Diagnostic Studies
11
Thoracic, aortic arch and abdominal aneurysms are significant vascular conditions that can present with various clinical manifestations and lead to serious complications. Understanding these manifestations and the appropriate diagnostic studies is essential for effective management and treatment.Thoracic Aortic AneurysmsThoracic aortic aneurysms often remain asymptomatic until they reach a size that impinges on adjacent structures. They typically cause deep, diffuse chest pain that radiates to...
11
01:30Aneurysm I: Introduction
16
An aortic aneurysm is a localized outpouching or dilation at a weak point in the artery wall. It may involve different parts of the aorta, such as the abdominal aorta, aortic arch, or thoracic aorta.Etiological factorsSeveral disorders are associated with aortic aneurysms.Congenital causes, such as primary connective tissue disorders like Marfan syndrome, impact the integrity and strength of connective tissues, notably affecting the aorta. Marfan syndrome is a genetic disorder that specifically...
16
01:26Aneurysm III: Interprofessional Care
13
Aneurysm management involves either conservative medical therapy or surgical intervention, depending on the size and symptoms of the aneurysm. Conservative management is generally reserved for smaller, asymptomatic aneurysms, while larger or symptomatic aneurysms often necessitate surgical repair.Conservative Medical TherapyFor small, asymptomatic aneurysms, particularly abdominal aortic aneurysms (AAA) less than 5.5 centimeters in diameter, conservative medical therapy is recommended. This...
13