60岁以下患者的白内障与氧化压力有关吗?
Hanna Lesiewska1, Alina Woźniak2, Paweł Reisner1
1Department of Ophthalmology, The Nicolaus Copernicus University, Ludwik Rydygier's Collegium Medicum, 85-094 Bydgoszcz, Poland.
Biomedicines
|May 27, 2023
概括
60岁以下的白内障患者的抗氧化酶活性和维生素水平较低,氧化应激标志物增加. 抗氧化剂补充可能有利于这一群体.
科学领域:
- 眼科医生 眼科 眼科
- 生物化学 生物化学
- 老年学是指老年学的学科.
背景情况:
- 氧化应激与白内障的发展有关.
- 早期出现的白内障 (60岁以下) 可能有不同的潜在机制.
- 系统性抗氧化剂状况需要在年轻的白内障患者中进一步调查.
研究的目的:
- 评估60岁以下白内障患者的全身抗氧化剂状况.
- 为了比较白内障患者和对照者之间的抗氧化酶活性和氧化应激标志物.
- 在这个年龄组中调查氧化应激和白内障形成之间的关系.
主要方法:
- 在红细胞中测量了超氧化脱酶 (SOD),酶 (CAT) 和谷氨过氧化酶 (GPx) 的酶活性.
- 量化了维生素A和E的血度.
- 作为氧化损伤标志物,确定了马隆迪甲 (MDA),联二烯 (CD) 和蛋白碳基 (PC) 的水平.
主要成果:
- 白内障患者的SOD和GPx活性显著降低,血维生素A和E度降低.
- 在白内障患者中观察到血和红细胞度 (MDA) 的升高.
- 在白内障患者中,较高的蛋白质碳烯 (PC) 和合二烯 (CD) 水平表明脂质和蛋白质氧化增加.
结论:
- 60岁以下人群的白内障发病率与抗氧化剂防御能力减弱以及脂质和蛋白质氧化率升高有关.
- 这些发现表明氧化应激在早期白内障的发病过程中起着重要作用.
- 抗氧化剂补充可能是这个患者群体潜在的有益的治疗策略.
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