作为COVID-19严重程度的诊断和预后标记物的Adipokines
Thomas Grewal1, Christa Buechler2
1School of Pharmacy, Faculty of Medicine and Health, University of Sydney, Sydney, NSW 2006, Australia.
Biomedicines
|May 27, 2023
概括
肥胖增加了COVID-19的严重程度. 在严重急性呼吸系统综合征冠状病毒2型 (SARS-CoV-2) 感染患者中,流通中的亚迪波金如加列-3和抵抗素具有诊断和预后价值.
科学领域:
- 免疫学 免疫学 免疫学
- 代谢综合征是代谢综合征的一种.
- 传染性疾病 传染性疾病
背景情况:
- 肥胖与SARS-CoV-2感染的严重结果有关.
- 肥胖的脂肪组织功能障碍会导致炎症并损害免疫功能.
- 这会影响病毒感染的易感性和从病毒感染中恢复.
研究的目的:
- 审查和关联阿迪波金水平与COVID-19的进展和结果.
- 在肥胖的COVID-19患者中识别诊断和预后标志物.
- 探索阿迪波金在SARS-CoV-2病原发生中的作用.
主要方法:
- 对SARS-CoV-2感染患者阿迪波金水平的研究进行系统审查.
- 分析循环中的阿迪波基因含量,包括海默林,阿迪波涅克丁,莱普,抵抗素,加勒克-3,阿佩林和维斯法丁.
- 阿迪波金水平与疾病严重程度和结果的相关性.
主要成果:
- 与COVID-19相关的几种阿迪波金 (化学素,阿迪波内克丁,莱普,抵抗素,加勒丁-3) 已被研究.
- 对于COVID-19中阿佩林和维斯法廷的数据有限.
- 循环中高水平的加勒-3和抵抗素水平与COVID-19的诊断和预后价值有关.
结论:
- 阿迪波金在SARS-CoV-2感染期间调节免疫反应中发挥作用.
- 循环中的 galectin-3 和resistin 显示为COVID-19 的生物标志物具有前景.
- 需要进一步的研究,以充分阐明所有阿迪波金在COVID-19中的作用.
相关概念视频
01:19Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers
127
Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
127
01:30Acute Kidney Injury IV: Diagnostic Studies and Prevention
41
Accurate diagnosis and effective prevention are critical in managing Acute Kidney Injury (AKI), which is linked to high mortality rates ranging from 10% to 80%. Timely recognition of at-risk patients and careful monitoring can significantly reduce the likelihood of kidney damage.Diagnostic Assessments:The diagnostic process starts with a comprehensive medical history to identify prerenal, intrarenal, and postrenal causes.Prerenal causes, such as dehydration, hypotension, or blood loss, should...
41
01:20Blood Studies for Cardiovascular System I: Cardiac Biomarkers
206
Cardiac biomarkers are enzymes, proteins, and hormones released into the blood when cardiac cells are injured. They are powerful tools for triaging.
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...
206
01:29Acute Kidney Injury III: Clinical Manifestations
45
Acute Kidney Injury (AKI) progresses through distinct clinical phases: the oliguric, diuretic, and recovery phases, each marked by unique manifestations and challenges.Oliguric Phase:The oliguric phase is the initial stage of AKI, typically lasting 10 to 14 days. This phase is marked by a significant reduction in urine output, usually less than 400 mL per day, indicating decreased kidney function. Fluid retention is a prominent feature, leading to symptoms such as edema, hypertension, and...
45
01:27Atherosclerosis II: Clinical Manifestations and Diagnostic Tests
18
Atherosclerosis is a progressive disorder that leads to the thickening and narrowing of arterial walls due to plaque buildup. This condition can cause various symptoms depending on the arteries affected:Coronary Artery Disease (CAD): This condition affects the coronary arteries and may lead to chest pain (angina), shortness of breath (dyspnea), heart attacks, and other heart disease symptoms.Cerebrovascular Disease: This affects blood flow to the brain, causing transient ischemic attacks (TIAs)...
18
01:30Acute Pancreatitis II: Clinical Manifestations and Management
159
Acute pancreatitis presents a complex medical emergency characterized by rapid onset inflammation of the pancreas, demanding timely diagnosis and management to prevent complications. The condition primarily manifests through severe upper abdominal pain that often radiates to the back. This pain intensifies following the consumption of fatty foods. Accompanying symptoms such as nausea, vomiting, abdominal distention, fever, dyspnea, cyanosis, and jaundice can vary in intensity but significantly...
159