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GLP-1增加了流通中的勒素水平在干部Vagotomized老鼠

Tiago Morais^1,2, Sofia S Pereira^1,2, Sara Andrade^1,2

¹Endocrine and Metabolic Research, UMIB-Unit for Multidisciplinary Research in Biomedicine, ICBAS-Instituto de Ciências Biomédicas Abel Salazar, Universidade do Porto, 4050-313 Porto, Portugal.

|May 27, 2023

概括

迷走神经对于调节体重和能量平衡至关重要. 它还调解了葡萄糖类-1 (GLP-1) 对食欲和身体成分的影响.

科学领域:

神经科学是一个神经科学.
内分泌学在内分泌学.
代谢过程中的代谢.

背景情况:

类似葡萄糖-1 (GLP-1) 是一种关键的肠道激素,通过肠-大脑轴参与调节能量平衡.
迷走神经在调解GLP-1对能量平衡的影响中的作用尚未完全理解.

研究的目的:

研究迷走神经在全身能量恒温中的作用.
要确定迷走神经是否介导GLP-1对能量平衡的影响.

主要方法:

在小鼠身上进行了骨干性阴道切除术,假操作的小鼠作为对照.
评估的参数包括饮食行为,体重,脂肪组织 (WAT和BAT) 百分比,休息能量消耗 (REE) 和对GLP-1的反应.
在实验室中,从内脏脂肪组织 (VAT) 扩展物分泌的瘦素分泌量也得到了评估.

主要成果:

与对照组相比,被吸毒的老鼠的食物摄入量,体重和脂肪组织质量都减少了,BAT/WAT比率更高,但与对照组相比,REE类似.
禁食时的格林林水平升高,而葡萄糖和胰岛素水平较低的vagotomized老鼠.
与对照者相比,GLP-1的使用导致了的厌食性反应和血中瘦素的增加,尽管在体外GLP-1没有改变从VAT分泌的瘦素分泌.

结论:

迷走神经通过影响食物摄入量,体重和身体组成,显著影响能量平衡.
迷走神经对于调解GLP-1的厌食效应至关重要.
研究结果表明,GLP-1-素轴依赖于阴道肠-大脑通路.

关键词:

这就是GLP-1.脂肪组织的脂肪组织.勒普丁是一种素.鼠标鼠标鼠标鼠标鼠标这是一种vagotomy.

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