微生物群代谢失败是大动脉假体后术后并发症的危险因素
Natalia Beloborodova1, Alisa Pautova1, Marina Grekova2
1Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology, 25-2 Petrovka Str., 107031 Moscow, Russia.
Biomedicines
|May 27, 2023
概括
由芳香微生物代谢物 (AMM) 表示的改变肠道微生物代谢,与大动脉动脉瘤手术中的术后并发症有关. 监测这些代谢物可能有助于预测和预防手术问题.
科学领域:
- 心血管外科心血管外科
- 微生物组研究 微生物组研究
- 代谢学 代谢学 代谢学
背景情况:
- 手术后的并发症是心血管外科手术中的一个重大挑战,特别是对于患有大动脉动脉瘤的患者.
- 改变肠道微生物群对这些并发症的影响是一个越来越感兴趣的领域.
研究的目的:
- 研究大动脉动脉瘤患者的初始或获得的微生物群代谢障碍和术后并发症之间的关系.
- 为了监测血中特定芳香微生物代谢物 (AMM) 的水平,在手术前和后进行手术.
主要方法:
- 试点研究涉及79名大动脉动脉瘤患者 (36名没有并发症,43名有并发症) 和48名健康志愿者.
- 手术前和手术后6小时收集的血清样本.
- 循环中的芳香微生物代谢物 (AMM) 的量化.
主要成果:
- 与健康志愿者相比,在大动脉动脉瘤患者手术前观察到与败血症相关的AMM水平较高 (p < 0.001).
- 在术后,出现并发症的患者的AMM水平明显高于没有出现并发症的患者 (p = 0.001).
- ROC分析表明,曲线下的面积为0.7,截止值为2.9μmol/L,赔率比为5.5.
结论:
- 微生物群代谢受损在复杂的重建性大动脉手术后的并发症的发展中起着至关重要的作用.
- 这些发现支持探索针对微生物群代谢的新型预防策略.
更多相关视频
相关概念视频
Peritoneal Dialysis II: Peritoneal Dialysis Systems and Complications
48
Peritoneal dialysis (PD) is a medical process that removes waste products and excess fluid from the body using the peritoneal membrane as a natural filter.Peritoneal Dialysis MethodsSeveral methods can be used for peritoneal dialysis, including Acute Intermittent Peritoneal Dialysis, Continuous Ambulatory Peritoneal Dialysis, and Automated Peritoneal Dialysis, also known as Continuous Cyclic Peritoneal Dialysis.Acute Intermittent Peritoneal Dialysis (AIPD) is used for patients with uremic...
48
Factors Affecting the Risk of Infection
12.1K
The hosts' susceptibility to infection depends on several factors. The integrity of the skin and mucous membranes helps protect the body against microbial attacks. When the skin is altered, the chance of infection, limb loss, and even death increases.
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
12.1K
Aneurysm III: Interprofessional Care
13
Aneurysm management involves either conservative medical therapy or surgical intervention, depending on the size and symptoms of the aneurysm. Conservative management is generally reserved for smaller, asymptomatic aneurysms, while larger or symptomatic aneurysms often necessitate surgical repair.Conservative Medical TherapyFor small, asymptomatic aneurysms, particularly abdominal aortic aneurysms (AAA) less than 5.5 centimeters in diameter, conservative medical therapy is recommended. This...
13
Aneurysm IV: Nursing Management
11
Vigilant monitoring for aneurysm rupture is essential for patients undergoing aortic surgery.Preoperative Nursing ManagementContinuously monitor the patient for manifestations of aneurysm rupture, such as pallor, weakness, tachycardia, hypotension, abdominal, back, groin, or periumbilical pain, changes in consciousness, and a pulsating abdominal mass. Regularly assess the patient's peripheral pulses.Instruct the patient to consume a clear liquid diet the day before surgery and administer...
11
Endocarditis III: Medical Management
9
Infective endocarditis management involves a multifaceted approach encompassing infection prevention, lifestyle modifications, pharmacological therapy, and surgical management.Infection Prevention:Hand Hygiene: Thorough handwashing is crucial to prevent the spread of infection. Hand hygiene should be performed regularly, especially before and after using the restroom.Oral Hygiene: Good oral hygiene is essential. It includes brushing teeth immediately after waking up and before bed, flossing...
9
Bacterial Signaling
33.0K
Bacterial signaling can occur within bacteria (intracellular) or between bacteria (intercellular). At times, a group of bacteria behaves like a community. To achieve this, they engage in quorum sensing, the perception of higher cell density that causes changes in gene expression. Quorum sensing involves both extracellular and intracellular signaling. The signaling cascade starts with a molecule called an autoinducer (AI). Individual bacteria produce AIs that move out of the bacterial cell...
33.0K


