在COVID-19相关的凝血病中NETosis和补充激活的作用
Emily Parissa Ghanbari1,2, Kai Jakobs1,2, Marianna Puccini1,2
1Department of Cardiology, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, 12203 Berlin, Germany.
Biomedicines
|May 27, 2023
概括
中性粒细胞外细胞陷 (NETosis) 和补充标记在COVID-19患者中升高,使他们与其他感染区别开来. 这些标记与疾病严重程度相关,可以识别患有免疫血栓形成风险的患者.
科学领域:
- 免疫学 免疫学 免疫学
- 病理学 病理学 病理学
- 传染性疾病 传染性疾病
背景情况:
- 炎症诱导的凝血病是COVID-19的一个重要并发症.
- 中性粒细胞外细胞陷 (NETosis) 和补体激活与COVID-19的发病因子有关.
- 了解NETosis,补充和血栓生成性之间的相互作用对于管理严重的COVID-19至关重要.
研究的目的:
- 评估COVID-19患者中NETosis和补充标志物之间的关联.
- 调查这些标志物与血栓发生率和疾病严重程度的关系.
- 根据NETosis和补充资料,将COVID-19与其他肺部感染区分开来.
主要方法:
- 对患有SARS-CoV-2感染 (COVpos) 和其他呼吸道感染 (COVneg) 的住院患者进行比较研究.
- 测量NETosis标志物 (MPO/DNA复合体),凝血参数,血小板计数和补充标志物 (C3,C5,C5b-9) 的测量.
- 标志物和临床严重性得分 (SOFA) 之间的相关性分析.
主要成果:
- 在COVpos患者中,NETosis,凝血,血小板和补充标记显著升高,特别是那些患有严重疾病的患者.
- NETosis标志物与凝血,血小板和补充标志物相关,特别是在COVpos患者中.
- 补充标志物 (C3,C5,C5b-9) 在重病的COVpos患者中显示出与疾病严重程度 (SOFA评分) 的显著关联.
结论:
- NETosis和补体系统是COVID-19炎症和临床严重性的组成部分.
- 升高的NETosis和补充标志物区分COVID-19与其他肺部感染.
- 补充标记物C5可以作为一种潜在的生物标记物,用于识别具有免疫血栓形成高风险的COVID-19患者.
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