先进的图像J分析退行性获得的形病变,使用基于光学连贯性断层扫描的技术
Ioana Damian1, George-Adrian Muntean1, Larisa-Bianca Galea-Holhoș2
1Department of Ophthalmology, "Iuliu Hatieganu" University of Medicine and Pharmacy, 8 Victor Babeș Street, 400012 Cluj-Napoca, Romania.
Biomedicines
|May 27, 2023
概括
在与年龄相关的黄斑变性 (AMD) 中获得的形病变显示了视网膜色素上皮质厚度的增加和外核层厚度的减少. 反VEGF注射并没有改善治疗眼睛的视力敏度.
科学领域:
- 眼科医生 眼科 眼科
- 视网膜疾病 视网膜疾病
- 医疗成像医学成像
背景情况:
- 获得的形病变 (AVL) 与各种视网膜疾病有关,包括与年龄相关的黄斑变性 (AMD).
- 了解AVL演变对于管理AMD进展至关重要.
研究的目的:
- 在AMD患者中描述AVL的演变.
- 通过光学连贯断层扫描 (OCT) 评估AVL对视网膜层的影响.
主要方法:
- 利用了OCT技术和ImageJ软件进行定量分析.
- 测量了AVL的大小,密度以及视网膜色素表皮质 (RPE) 和外核层 (ONL) 厚度的变化.
- 监控外部限制膜 (ELM) 和圆形区域 (EZ) 的结构完整性.
主要成果:
- 与对照组相比,形组的平均RPE厚度 (45.89微米) 显著增加,ONL厚度 (77.94微米) 减少.
- 在55.5%的AVL眼睛中观察到连续ELM,在22.2%的AVL眼睛中观察到连续EZ.
- 在随访期间,AVL体积没有显著变化 (p=0.725);抗VEGF治疗没有显示BCVA改善.
结论:
- 增加的RPE厚度可能表明增生症,而减少的ONL厚度表明AVLs对光受体的影响.
- 在AMD中AVL在11个月的中位随访期间,其体积似乎没有显著变化.
- 目前的抗VEGF治疗策略可能无法恢复AVL眼睛的视力敏度.
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