调节脂肪组织形成和功能的原蛋白.
Iida Jääskeläinen1, Tiina Petäistö1, Elahe Mirzarazi Dahagi2
1ECM-Hypoxia Research Unit, Faculty of Biochemistry and Molecular Medicine, University of Oulu, 90014 Oulu, Finland.
Biomedicines
|May 27, 2023
概括
肥胖会破坏脂肪组织 (AT) 功能,影响代谢健康. 本综述强调了AT中的原体和细胞外矩阵成分如何对其发育,功能和在代谢疾病中的作用至关重要.
科学领域:
- 生物化学 生物化学
- 细胞生物学 细胞生物学
- 代谢研究研究 代谢研究
背景情况:
- 全球肥胖率的上升与代谢性疾病 (如2型糖尿病,脂质失调和脂肪肝) 有关.
- 脂肪组织 (AT),除了脂质储存,功能作为内分泌系统,其功能障碍有助于系统代谢功能障碍.
- 细胞外基质 (ECM),包括基底膜 (BM),围绕着脂肪细胞,影响其功能和分化.
研究的目的:
- 审查脊椎动物原在脂肪组织发育和功能中的作用.
- 讨论其他ECM成分,如纤维内素在脂肪组织中的参与.
- 探索脂肪组织原体在代谢性疾病中的功能.
主要方法:
- 关于脊椎动物原体和脂肪组织中的ECM成分的文献综述.
- 分析原蛋白在脂肪细胞分化和功能中的作用.
- 检查原蛋白在脂肪组织纤维化和代谢疾病中的参与.
主要成果:
- 特定的原蛋白,特别是基底膜相关的原蛋白,对于脂肪组织功能和脂肪细胞分化至关重要.
- 脂肪组织纤维化,以原积累为标志,在肥胖中损害了AT功能.
- 纤维菌素是另一个关键的ECM成分,影响脂肪组织生物学.
结论:
- 脊椎动物的原蛋白是脂肪组织发育,功能和ECM完整性的关键调节剂.
- 功能障碍的原体和脂肪组织中的ECM重塑与肥胖相关的代谢疾病有关.
- 向原蛋白和ECM组件可能为代谢障碍提供治疗策略.
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