在HF患者中,点性尿氨酸度的预后值及其与身体组成参数的关系
Jolanta Malinowska-Borowska1, Małgorzata Piecuch1, Patryk Szlacheta1
1Department of Chronic Diseases and Civilization-Related Hazards, Faculty of Public Health in Bytom, Medical University of Silesia in Katowice, 41-902 Bytom, Poland.
Biomedicines
|May 27, 2023
概括
在心力衰竭 (HF) 患者的下点尿氨酸度 (SUCR) 表明预后更差,但这种关联与流体过载有关,而不是肌肉衰竭. 这一发现为高频管理提供了一种实际的预测工具.
科学领域:
- 心脏病学 心脏病学
- 腎臟病學 (nephrology) 是一種醫學.
- 生物标志物 生物标志物
背景情况:
- 在心力衰竭 (HF) 中,24小时尿路肌素分泌量低与肌肉衰竭和预后不佳有关.
- 斑点尿蛋白度 (SUCR) 是一个潜在的,实际的预后标记在HF.
- 在未经选择的HF人群中,SUCR的预后价值及其与人体组成和液体过载的关系仍然没有研究.
研究的目的:
- 为了评估 SUCR 在未经选择的 HF 群体中的预后值.
- 评估SUCR和身体成分标记物之间的关联.
- 在HF患者中研究SUCR和体积过载标记之间的关系.
主要方法:
- 911名高压患者接受了SUCR测量和双X射线吸收计 (DEXA) 测量身体组成.
- 单变量和多变量分析确定了日志 SUCR 的预测因素.
- 患者被分为四分之一的SUCR分层,用于对3年的结果分析.
主要成果:
- SUCR与无脂肪体重的相关性很弱,但与循环利尿剂剂量,NTproBNP和血清的相关性更强.
- 较低的SUCR四分位数与较高的死亡率有关 (80%的风险增加与顶部四分位数相比).
- 在调整了利尿剂量和矿物质皮质醇受体对抗剂的使用后,SUCR的预后意义消失了.
结论:
- 在HF患者中,较低的SUCR水平与较差的结果相关,独立于身体成分.
- 液体过载似乎是将较低的SUCR与高频死亡率的增加联系起来的主要因素.
- 根据液体状况调整后的SUCR可以作为心力衰竭的实际预后指标.
更多相关视频
05:15Cutoff Value of Phase Angle by Bioelectrical Impedance Analysis at Admission as a Prognostic Factor in Patients with Acute Heart Failure
Published on: June 10, 2025
144
13:35Segmentation and Linear Measurement for Body Composition Analysis using Slice-O-Matic and Horos
Published on: March 21, 2021
10.6K
相关概念视频
01:17Factors Affecting Renal Clearance: Renal Impairment
125
Renal dysfunction significantly impairs the renal clearance of drugs, leading to potential complications in drug therapy. Renal failure, which can be caused by various factors, poses a significant challenge in the elimination of drugs from the body.
One condition associated with renal failure is uremia. Uremia is characterized by impaired glomerular filtration and fluid accumulation in the body. This condition hinders the renal clearance of drugs, resulting in drug accumulation and potential...
One condition associated with renal failure is uremia. Uremia is characterized by impaired glomerular filtration and fluid accumulation in the body. This condition hinders the renal clearance of drugs, resulting in drug accumulation and potential...
125
01:24Serum Studies: Renal Function Tests
25
Renal function tests are crucial for assessing kidney health, monitoring disease progression, and evaluating the kidneys' efficiency in waste elimination, fluid balance, and electrolyte regulation. These tests offer critical insights into kidney function, even though routine measurements may appear normal until there is a significant decline in the glomerular filtration rate or GFR. Typically, signs of kidney impairment only become evident when the GFR falls to about 50% of its normal level.
25
01:19Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers
127
Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
127
01:23Renal Clearance
1.1K
The glomerular filtration rate (GFR) is a critical marker of kidney function, reflecting the efficiency of filtration by the glomeruli. Renal clearance of specific substances, such as inulin or creatinine, is commonly used to measure GFR.
Renal clearance refers to the volume of plasma cleared of a specific substance, such as creatinine, per unit of time. To measure clearance, urine samples are collected over a 24-hour period during each bladder voiding, followed by a single blood sample at the...
Renal clearance refers to the volume of plasma cleared of a specific substance, such as creatinine, per unit of time. To measure clearance, urine samples are collected over a 24-hour period during each bladder voiding, followed by a single blood sample at the...
1.1K
01:22Heart Failure VI: Adjunct Therapies
17
Additional therapies for treating patients with heart failure (HF) may include procedural interventions, supplemental oxygen, the management of sleep disorders, and nutritional therapy.Procedural InterventionsImplantable Cardioverter-Defibrillator: For patients at risk of life-threatening arrhythmias due to severe left ventricular dysfunction, an Implantable Cardioverter-Defibrillator (ICD) can detect and terminate these arrhythmias, preventing sudden cardiac death and improving survival rates.
17
01:22Heart Failure Drugs: Diuretics
430
Heart failure and kidney perfusion are interconnected in a complex way. Reduced renal perfusion and venous congestion are two significant factors that contribute to renal dysfunction in heart failure. The kidneys, primarily responsible for fluid balance in the body, are adversely affected due to compromised cardiac output and increased venous pressure. In response to reduced renal perfusion, the kidneys activate neurohumoral mechanisms to restore balance. However, these mechanisms can be...
430