淋巴细胞子组和肺结节可以预测沙尔科病的进展
Edvardas Danila1,2, Regina Aleksonienė2, Justinas Besusparis3,4
1Clinic of Chest Diseases, Immunology and Allergology, Faculty of Medicine, Vilnius University, 03101 Vilnius, Lithuania.
Biomedicines
|May 27, 2023
概括
在血液和支气管支气管洗液中识别特定的免疫细胞标记物可以帮助预测肺性沙科毒症的进展. 这些生物标志物,以及CT扫描的发现,提供了对疾病过程的洞察力.
科学领域:
- 肺部医学 肺部医学
- 免疫学 免疫学 免疫学
- 放射学 放射学是一门学科.
背景情况:
- 在诊断时评估肺性沙丘症的预后至关重要.
- 确定可靠的生物标志物用于疾病过程预测是研究的优先事项.
研究的目的:
- 为了调查肺部类瘤的预后因素.
- 专注于细胞免疫炎症标志物作为潜在的预测因素.
主要方法:
- 前性研究,随访2年.
- 分析血液中的淋巴细胞激活标记物,支气管支气管洗液 (BALF) 和肺活检.
- 与计算机断层扫描 (CT) 模式和肺功能测试的相关性.
主要成果:
- 五个标志物与疾病进展 (恶化肺功能/CT变化) 有显著的负相关性.
- 这些包括血液中的CD4+CD31+和CD4+CD44+T淋巴细胞,BALF CD8+CD31+和CD8+CD103+T淋巴细胞.
- 初始CT上肺结节的数量也预测了进展.
结论:
- 特定的血液和BALF免疫标记物,以及CT检测结果,与不同类型的型发病结局有关.
- 这些已识别的标志物可以作为沙尔科毒症进展的合理预测指标.
相关概念视频
Pulmonary Tuberculosis III
385
Tuberculosis (TB) is a contagious infection primarily affecting the lung parenchyma but which can also affect other body parts. TB can be classified based on disease development, presentation, and the affected anatomical site.
The first classification is based on the development of the disease, and it includes the following categories:
The first classification is based on the development of the disease, and it includes the following categories:
385
Lymphoid Cells and Tissues
1.3K
Lymphoid cells and tissues are integral to the immune system, which is crucial in maintaining our body's defense against harmful pathogens. They form the building blocks of lymphoid organs, which include the spleen, thymus, and lymph nodes.
Lymphoid cells consist of various types of immune system cells. These include B and T lymphocytes, which are responsible for producing antibodies and killing infected cells, respectively. Dendritic cells act as messengers between the innate and adaptive...
Lymphoid cells consist of various types of immune system cells. These include B and T lymphocytes, which are responsible for producing antibodies and killing infected cells, respectively. Dendritic cells act as messengers between the innate and adaptive...
1.3K
Pulmonary Tuberculosis IV
182
Tuberculosis, more commonly referred to as TB, is an infectious disease stemming from Mycobacterium tuberculosis. While it primarily impacts the lungs, TB can also affect other body areas. Given its severity and global impact, timely and accurate diagnosis is crucial for controlling its spread and improving patient outcomes.
Several diagnostic approaches are used to detect TB. The conventional method is the Tuberculin Skin Test (TST), also known as the Mantoux test. However, this method has...
Several diagnostic approaches are used to detect TB. The conventional method is the Tuberculin Skin Test (TST), also known as the Mantoux test. However, this method has...
182
Secondary Lymphoid Organs
1.7K
Secondary organs, including lymph nodes, the spleen, and mucosa-associated lymphoid tissue (MALT), work harmoniously to protect us from disease and infection.
The spleen is a vital organ in the lymphatic system, nestled in the upper left side of the abdomen. It is composed of two primary regions: the red pulp and the white pulp, each having distinct functions. The red pulp performs a significant role in blood filtration. It efficiently purges the blood of old or damaged red blood cells and...
The spleen is a vital organ in the lymphatic system, nestled in the upper left side of the abdomen. It is composed of two primary regions: the red pulp and the white pulp, each having distinct functions. The red pulp performs a significant role in blood filtration. It efficiently purges the blood of old or damaged red blood cells and...
1.7K
Pulmonary Tuberculosis II
282
Tuberculosis, or TB, is a bacterial infectious disease caused by Mycobacterium tuberculosis. While its primary impact is on the lungs, leading to pulmonary tuberculosis, it can also affect various other organs, a condition referred to as extrapulmonary tuberculosis.
Here is a detailed explanation of its pathophysiology:
Transmission: The process begins when a person inhales droplet nuclei containing M. tuberculosis. These are typically released into the air when an individual with pulmonary or...
Here is a detailed explanation of its pathophysiology:
Transmission: The process begins when a person inhales droplet nuclei containing M. tuberculosis. These are typically released into the air when an individual with pulmonary or...
282
Primary Lymphoid Organs
1.7K
Primary lymphoid organs are pivotal in the formation, development, and maturation of lymphocytes, the white blood cells that serve as the backbone of our immune system. This crucial function underscores their fundamental role in maintaining our overall health and immunity. The two primary lymphoid organs of prime importance are the red bone marrow and the thymus.
The red bone marrow is a soft, spongy tissue nestled in the interior of long bones such as the humerus and femur. It is the site...
The red bone marrow is a soft, spongy tissue nestled in the interior of long bones such as the humerus and femur. It is the site...
1.7K


