限制饮食会重置消化系统的外周时钟
Kazuo Nakazawa1, Minako Matsuo2, Naobumi Kimura2
1Department of Applied Chemistry and Life Science, Toyohashi University of Technology, Toyohashi 441-8580, Japan.
Biomedicines
|May 27, 2023
概括
限制饮食的肠道包括外围消化系统的时钟,但不包括中央SCN时钟. 在受限养期间,食道时钟显示出更强的SCN调节,而不是食道时钟.
科学领域:
- 时间生物学 时间生物学
- 分子生物学分子生物学
- 生理学 生理学 生理学
背景情况:
- 有机体拥有与地球自转同步的内部昼夜节律.
- 上神核 (SCN) 包含中央昼夜时钟,而外围组织有自己的时钟.
- 周期1 (Per1) 是哺乳动物中昼夜节律的关键分子调节器.
研究的目的:
- 调查限制性养 (RF) 是否会导致消化道中的外围时钟.
- 为了确定射频对中央SCN时钟和外围胃肠道时钟的影响.
- 在射频条件下比较不同消化组织的吸收能力.
主要方法:
- 生产Period1 luciferase (Per1::luc) 转基因小鼠,以实时监测Per1基因表达.
- 在组织样本中分析生物发光节奏,使用共弦拟合.
- 在休息期间,小鼠接受4小时的限制性食,并与任意食进行比较.
主要成果:
- 消化管和阴中的外周时钟在RF下表现出显著的相位变化 (5-11小时).
- 在7天的RF中,上神经核中的中央SCN时钟在很大程度上保持不变.
- 来自RF的禁食信号引入了消化器外围时钟,但不是SCN时钟.
- 食道钟表表现出回归基线节律的趋势,这表明SCN调节比内钟表更强.
结论:
- 消化系统中的外周时钟,包括食道和阴,可以独立地被RF诱导的禁食信号所带动.
- 在休息阶段,SCN时钟可以通过食时间表抵御被带.
- 外围时钟之间存在差异调节,食道与阴相比,对SCN的依赖性更强.
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