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Updated: Jul 29, 2025

Generation of 3D Whole Lung Organoids from Induced Pluripotent Stem Cells for Modeling Lung Developmental Biology and Disease
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从诱导的多能干干细胞中快速生成肺器官,通过共同培养内皮和中皮原生细胞来建模肺部疾病

Adam Mitchell1, Chaowen Yu1,2, Xiangjun Zhao1

  • 1Division of Evolution, Infection and Genomics, School of Biological Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester M13 9PL, UK.

Biomedicines
|May 27, 2023
PubMed
概括

研究人员使用多种细菌层方法快速制造了肺器官. 这些来自诱导多能干细胞的3D有机体,表达关键的肺标记物和ACE2,有助于呼吸系统疾病研究.

关键词:
这就是SARS-CoV-2病毒.膜上皮细胞是膜上皮细胞前部前肠内皮的前部前肠内皮.通过iPSC疾病建模.诱导多能干细胞 (iPSCs) 是一种这里是 mesoderm 和 mesoderm 的区别.肺部有机物质 肺部有机物质

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Embryonic and induced pluripotent stem cells are excellent models for disease research because of their ability to self-renew and differentiate into most cell types. Somatic cells from a patient are isolated and reprogrammed into induced pluripotent stem cells or iPSCs. These iPSCs are later differentiated into the desired cell type, which mirrors the diseased cell of the patient. In this way, disease models have been created for investigating diseases such as Down syndrome, type I diabetes,...
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