空气污染:痴呆症的一个默默的关键驱动因素
Pawel Serafin1, Malgorzata Zaremba1,2, Dorota Sulejczak3
1Military Institute of Hygiene and Epidemiology, 01-163 Warsaw, Poland.
Biomedicines
|May 27, 2023
概括
空气污染,特别是细颗粒物 (PM2.5),越来越多地与痴呆风险有关. 本综述审查了证据,建议的大脑机制,以及目前痴呆症治疗的局限性.
科学领域:
- 环境健康 环境健康
- 神经科学是一个神经科学.
- 公共卫生 公共卫生
背景情况:
- 柳叶刀委员会将空气污染确定为潜在的痴呆风险因素.
- 越来越多的证据表明细颗粒物 (PM) 和痴呆症之间存在因果关系.
- 有限的干预措施可以预防痴呆的发病.
研究的目的:
- 审查空气污染与痴呆症相关的最新证据.
- 专注于细颗粒物 (PM2.5).
- 概述空气污染物影响大脑的拟议机制.
主要方法:
- 基于人口的队列研究的审查.
- 分析有关空气质量和健康影响的科学文献.
- 检查拟议的生物途径.
主要成果:
- 越来越多的证据将空气污染暴露与痴呆症风险增加联系在一起.
- 细颗粒物 (PM2.5) 是一个关键的污染物.
- 提出的机制包括神经炎症和免疫反应激活.
结论:
- 空气污染是痴呆症的一个重要环境风险因素.
- 需要进一步的研究来阐明精确的机制,并为干预措施提供信息.
- 目前痴呆症治疗的局限性强调了预防策略的重要性.
相关概念视频
Dementia
144
Dementia is a collective term for cognitive disorders primarily affecting memory, thinking, and reasoning. It is not a specific disease but a syndrome, with Alzheimer's disease being the most common cause, accounting for approximately 60-80% of cases. Other types include vascular dementia, Lewy body dementia, and frontotemporal dementia. Dementia affects millions worldwide, particularly older adults, though it is not a normal part of aging.
The progression of dementia is generally gradual....
The progression of dementia is generally gradual....
144
Alzheimer's Disease: Overview
539
Alzheimer's Disease (AD) is a continually advancing neurodegenerative disorder, distinguished by escalating memory loss, cognitive dysfunction, and dementia. The disease unfolds in three stages: preclinical, mild cognitive impairment (MCI), and dementia. Its onset is insidious, and the progression gradual, with the cause not well explained by other disorders.
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ...
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ...
539
Psychoneuroimmunology: Diabetes and Cancer
50
Chronic stress has been linked to both the onset and progression of serious health conditions, including Type 2 diabetes and cancer. Type 2 diabetes, a widespread chronic illness, is closely associated with obesity and insulin resistance, both of which often worsen under stress. Studies indicate that men experiencing high levels of chronic stress face a 45% higher risk of developing diabetes compared to those with minimal stress. Stress triggers physiological responses that elevate blood...
50
Asthma-I: Introduction
2.7K
Asthma is a chronic respiratory ailment that requires careful management due to its varying symptoms and influencing factors. It is characterized by airway inflammation, bronchial hyperresponsiveness, and reversible airflow obstruction, leading to symptoms like wheezing, shortness of breath, chest tightness, and coughing. The symptom frequency and intensity may vary considerably over time. It is also linked to immune system responses to allergens and irritants, highlighting the complex...
2.7K
Chronic Obstructive Pulmonary Disease-I: Introduction
2.9K
Chronic Obstructive Pulmonary Disease (COPD) is a long-lasting respiratory condition requiring continuous attention and care. It is a progressive lung disease that leads to breathing challenges due to airflow obstruction. It manifests as persistent respiratory symptoms and restricted airflow resulting from abnormalities in the airways and alveoli, usually due to long-term exposure to harmful particles or gases. COPD mainly consists of two primary conditions: emphysema and chronic bronchitis.
2.9K
Chronic Obstructive Pulmonary Disease-II: Pathophysiology
2.9K
Chronic Obstructive Pulmonary Disease (COPD) pathophysiology is intricate and multifaceted, involving a complex interplay of physiological processes. Understanding these mechanisms is crucial for effectively managing and treating COPD. Here is an in-depth look at the critical elements in the pathophysiology of COPD:
Chronic Inflammation
Chronic Inflammation
2.9K


