检查点抑制剂诱导的结肠炎:一个更新
Giuseppe Losurdo1, Daniele Angelillo1, Nicolas Favia1
1Section of Gastroenterology, Department of Precision and Regenerative Medicine and Ionian Area, University of Bari "Aldo Moro", 70124 Bari, Italy.
Biomedicines
|May 27, 2023
概括
免疫检查点抑制剂 (ICI) 可能导致结肠炎,这是影响患者的常见副作用. 管理范围从轻度病例的支持性护理到严重ICI相关大肠炎的皮质类固醇和生物药物.
科学领域:
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
- 胃肠病学 胃肠病学
背景情况:
- 针对CTLA-4,PD-1和PD-L1的免疫检查点抑制剂 (ICI) 用于固体瘤.
- 通过ICI过度刺激免疫系统可能会导致不良影响,特别是ICI相关的大肠炎.
- 与ICI相关的结肠炎表现出腹和腹痛等症状,显著影响患者的生活质量.
研究的目的:
- 审查ICI相关大肠炎的临床表现,分级,组织学特征和管理策略.
- 为免疫检查点抑制剂诱导肠球炎提供当前治疗方法的概述.
主要方法:
- 关于ICI相关大肠炎的文献综述.
- 对临床表现,诊断标准和组织学发现的分析.
- 根据严重程度进行治疗干预的总结.
主要成果:
- 与ICI相关的结肠炎是癌症免疫治疗的常见和致残的副作用.
- 使用常用术语标准对不良事件 (CTCAE) 评级系统来评估严重程度.
- 组织学发现是非特异性的,但可以分为五种类型.
- 治疗包括支持性护理,抗腹药物,皮质类固醇,以及潜在的生物药物,如因弗利西马布或维多利祖马布,用于耐火病例.
结论:
- 与ICI相关的大肠炎的有效管理对于患者的福祉和治疗的延续至关重要.
- 从支持性护理到先进疗法,需要逐步的方法来管理ICI诱导的肠球炎.
- 进一步的研究可能会完善这种免疫疗法并发症的诊断和治疗策略.
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