瓦尔酸诱导的代谢综合征
Natalia A Shnayder1,2, Violetta V Grechkina1, Vera V Trefilova1,3
1Institute of Personalized Psychiatry and Neurology, Shared Core Facilities, V.M. Bekhterev National Medical Research Centre for Psychiatry and Neurology, 192019 Saint Petersburg, Russia.
Biomedicines
|May 27, 2023
概括
长期使用酸 (VPA) 可以导致代谢综合征 (MetS). 本综述探讨了血液和尿路生物标志物,用于预防和诊断患有神经和精神疾病的患者的VPA诱导的MetS.
科学领域:
- 药理学和毒理学 药理学和毒理学
- 代谢障碍 代谢障碍 代谢障碍
- 生物标志物发现发现
背景情况:
- 瓦尔酸 (VPA) 和它的盐是被广泛处方的精神药物.
- 长期使用VPA与不良药物反应 (ADRs) 相关,特别是代谢综合征 (MetS).
- 超标血清症是一种疾病集群,包括肥胖,高血压,高血糖症,脂质不良症和低HDL胆固醇.
研究的目的:
- 审查目前关于血液和尿路生物标志物的VPA诱导的MetS (VPA-MetS) 的研究.
- 突出需要一种更新的,多学科的方法来预防和诊断VPA-MetS.
- 探索代谢生物标志物在VPA-MetS.S.个性化医疗战略中的潜力.
主要方法:
- 对研究血液 (血清,血) 和尿路生物标志物的系统审查.
- 对VPA-MetS流行率和风险因素的现有文献进行分析.
- 综合与诊断和预测生物标志物潜力相关的发现.
主要成果:
- 鉴定与VPA-MetS相关的各种血液和尿路代谢生物标志物.
- 证据表明生物标志物可以帮助早期检测和风险分层.
- 讨论VPA-MetS呈现的异质性和个性化方法的需要.
结论:
- 代谢生物标志物有望为开发个性化策略进行VPA-MetS预防和诊断.
- 在患有神经,精神和成疾病的患者中,多学科的方法对于管理VPA-MetS至关重要.
- 对特定生物标志物的进一步研究是有必要的,以完善诊断和治疗干预措施.
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