产前抑郁症的细胞因子,化学因子和生长因子网络
Michael Maes1,2,3,4,5, Yoshiko Abe6,7, Wandee Sirichokchatchawan6,8
1Department of Psychiatry, Faculty of Medicine, Chulalongkorn University and King Chulalongkorn Memorial Hospital, the Thai Red Cross Society, Bangkok 10330, Thailand.
免疫系统的激活,包括M1巨细胞和T辅助细胞的形状,显著影响产前抑郁症的严重程度,独立于心理因素. 这些免疫变化对于理解和潜在治疗围产期情绪障碍至关重要.
科学领域:
- 围产期心理健康问题
- 免疫精神病学是一种精神病学.
- 生殖免疫学 生殖免疫学
背景情况:
- 神经免疫通路与产前和产后抑郁症有关.
- 围产期抑郁症是一个重大的公共卫生挑战.
- 了解超出心理压力因素的促成因素至关重要.
研究的目的:
- 调查免疫特征对产前抑郁症严重程度的影响.
- 为了区分免疫贡献与不良童年经历 (ACE),月经前综合征 (PMS) 和心理压力因素.
- 识别与产前抑郁症状相关的特定免疫标记物.
主要方法:
- 在120名使用Bio-Plex Pro 27-plex测试的孕妇中测试了免疫特征 (M1巨细胞,T辅助细胞,细胞因子).
- 评估免疫炎症反应系统 (IRS) 和补偿性免疫调节系统 (CIRS) 的指标.
- 使用爱丁堡产后抑郁量表 (EPDS) 来测量产前抑郁症的严重程度.
主要成果:
- 确定了一个压力-免疫-抑郁的表型,与上调的M1,Th-1,Th-2和IRS免疫配置以及特定的细胞因子 (例如IL-4,IL-6,IL-17) 相关.
- 免疫特征,不包括CIRS,与早期EPDS得分有显著的关联,独立于心理变量和PMS.
- 免疫特征从怀孕早期转移到怀孕晚期,IRS/CIRS比率增加;早期得分,不良经历和Th-2/Th-17表型预测了晚期抑郁症.
结论:
- 激活的免疫表型显著导致早期和晚期围产期抑郁症状.
- 免疫系统的激活在产前抑郁症中发挥着作用,超越了心理压力和PMS.
- 准免疫路径可能为围产期情绪障碍提供新的治疗策略.
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