在双相患者中,急性抑郁和缓解阶段对工作记忆任务的神经反应
Juliane Kopf1, Stefan Glöckner2, Heike Althen1
1Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, University Hospital, Goethe University Frankfurt, 60590 Frankfurt am Main, Germany.
Brain sciences
|May 27, 2023
概括
双极性障碍 (BD) 患者表现出工作记忆 (WM) 损失和前额叶皮层活化减少. 虽然WM的表现在缓解期间得到改善,但大脑活化仍然受到影响,特别是在苛刻的任务中.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 认知科学 认知科学
背景情况:
- 工作记忆 (WM) 缺陷是双相情感障碍 (BD) 的标志,严重影响日常功能.
- 了解BD中WM障碍的神经基础对于开发有效干预措施至关重要.
研究的目的:
- 为了调查工作记忆 (WM) 的表现和相关的前脑激活在双相障碍 (BD) 患者在急性和缓解阶段.
- 为了比较BD患者和健康对照者之间的大脑激活模式.
主要方法:
- 功能近红外光谱学 (fNIRS) 用于测量在n-back任务期间的前脑激活.
- 参与者包括急性抑郁 (n=32) 和缓解 (n=15) 阶段的BD患者,以及健康的对照组 (n=30).
主要成果:
- 与对照组相比,急性阶段的BD患者表现出较低的背侧前额叶皮层 (dlPFC) 激活的趋势 (p=0.08).
- 在缓解阶段,BD患者的dlPFC和腹侧前额皮层 (vlPFC) 激活率明显低 (p=0.02) 比对照组.
- 在BD的急性和缓解阶段之间,没有观察到dlPFC和vlPFC激活的显著差异.
结论:
- 在急性阶段,BD患者的工作记忆性能下降.
- 虽然WM的表现在缓解期间得到改善,但它仍然受到损害,特别是在高认知负载下.
- 前额叶皮层激活的持续变化可能是BD认知缺陷的基础,即使在症状缓解后也是如此.
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