Search research articles

关于 JoVE

概览领导团队博客 JoVE 帮助中心

作者

出版流程编辑委员会范围与政策同行评审常见问题投稿

图书馆员

用户评价订阅访问资源图书馆顾问委员会常见问题

研究

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments 存档

教育

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual 教师资源中心教师网站

使用条款与条件

相关概念视频

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序

Same author

Correction to: Regulation of Keap1-Nrf2 axis in temporal lobe epilepsy-hippocampal sclerosis patients may limit the seizure outcomes.

Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·2023

Same author

Regulation of Keap1-Nrf2 axis in temporal lobe epilepsy-hippocampal sclerosis patients may limit the seizure outcomes.

Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·2023

Same author

Dopamine and Glutamate Crosstalk Worsen the Seizure Outcome in TLE-HS Patients.

Molecular neurobiology·2023

Same author

Distinct expression and function of breast cancer metastasis suppressor 1 in mutant P53 glioblastoma.

Cellular oncology (Dordrecht, Netherlands)·2022

Same author

Endoplasmic reticulum stress and unfolded protein accumulation correlate to seizure recurrence in focal cortical dysplasia patients.

Cell stress & chaperones·2022

Same author

Preclinical animal studies in ischemic stroke: Challenges and some solutions.

Animal models and experimental medicine·2021

Search research articles

相关实验视频

Updated: Jul 29, 2025

Rat Model of Widespread Cerebral Cortical Demyelination Induced by an Intracerebral Injection of Pro-Inflammatory Cytokines

Rat Model of Widespread Cerebral Cortical Demyelination Induced by an Intracerebral Injection of Pro-Inflammatory Cytokines

Published on: September 21, 2021

在大鼠的坐骨神经中,手术诱导的脱化.

Rahul Shankar Rao Rayilla¹, Mur Naidu², Phanithi Prakash Babu¹

¹Department of Biotechnology and Bioinformatics, School of Life Sciences, University of Hyderabad, Hyderabad 500046, India.

|May 27, 2023

概括

一种新的手术方法在老鼠的坐骨神经中诱导脱髓化. 泰里弗卢诺米德治疗成功促进了回髓化和恢复运动功能,为外围神经损伤提供了潜在的治疗途径.

科学领域:

神经科学是一个神经科学.
再生医学是一种再生医学.
手术技巧手术技巧

背景情况:

周围神经损伤 (PNI) 通常涉及脱髓化,损害轴突周围的髓质.
目前用于诱导周围神经系统 (PNS) 脱髓化的动物模型有限.
坐骨神经损伤是常见的PNI模型,但受控的脱髓化诱导具有挑战性.

研究的目的:

开发和验证一种用于诱导大鼠坐骨神经脱髓化的手术技术.
调查特里弗卢诺米德 (TF) 对脱髓化和功能恢复的影响.
建立一个可靠的临床前模型来研究PNI和潜在的治疗方法.

主要方法:

在年轻的雄性Sprague Dawley大鼠身上进行了手术部分坐骨神经 suture (p-SNI).
组织学,免疫染色和传输电子显微镜 (TEM) 用于评估脱髓化,轴突损伤和髓修复.
用旋转棒测试来评估运动功能.
托里弗卢诺胺 (TF) 用于评估其治疗效果.

主要成果:

该p-SNI模型成功诱导了不同程度的脱髓化和髓损失.
组织学分析揭示了受伤后的轴突缩和轴突间隙.

关键词:

脱化是脱化的一种.复黄化是复黄化的一种.坐骨神经受伤的伤害是什么?里弗隆胺的使用方法

更多相关视频

Chronic Constriction of the Sciatic Nerve and Pain Hypersensitivity Testing in Rats

Chronic Constriction of the Sciatic Nerve and Pain Hypersensitivity Testing in Rats

Published on: March 13, 2012

In Vitro Myelination of Peripheral Axons in a Coculture of Rat Dorsal Root Ganglion Explants and Schwann Cells

In Vitro Myelination of Peripheral Axons in a Coculture of Rat Dorsal Root Ganglion Explants and Schwann Cells

Published on: February 10, 2023

相关实验视频

Last Updated: Jul 29, 2025

Rat Model of Widespread Cerebral Cortical Demyelination Induced by an Intracerebral Injection of Pro-Inflammatory Cytokines

Rat Model of Widespread Cerebral Cortical Demyelination Induced by an Intracerebral Injection of Pro-Inflammatory Cytokines

Published on: September 21, 2021

Chronic Constriction of the Sciatic Nerve and Pain Hypersensitivity Testing in Rats

Chronic Constriction of the Sciatic Nerve and Pain Hypersensitivity Testing in Rats

Published on: March 13, 2012

In Vitro Myelination of Peripheral Axons in a Coculture of Rat Dorsal Root Ganglion Explants and Schwann Cells

In Vitro Myelination of Peripheral Axons in a Coculture of Rat Dorsal Root Ganglion Explants and Schwann Cells

Published on: February 10, 2023

罗塔罗德的测试证实了p-SNI大鼠的显著运动功能缺陷.

TF治疗导致了运动功能的恢复,轴突修复和复髓化的证据.

结论:

一种新的手术方法有效地诱导了老鼠坐骨神经的脱髓化.
特里弗卢诺米德在促进PNI后的复髓化和功能恢复方面显示出显著的治疗潜力.
这项研究为研究PNI和评估新型治疗干预提供了有价值的模型.