探索与新生儿糖尿病相关的饮食-肠道微生物群-表观遗传学交叉
1Heart, Mind & Body Research Group, Griffith University, Gold Coast, QLD P.O. Box 4222, Australia.
Genes
|May 27, 2023
概括
新生儿糖尿病 (NDM) 与肠道微生物群的变化有关,可能受到孕期糖尿病 (GDM) 期间母亲饮食的影响. 这篇评论探讨了饮食,肠道微生物和表观遗传学如何影响NDM基因表达.
科学领域:
- 新生儿科学 新生儿科学
- 内分泌学 在内分泌学.
- 微生物学 微生物学
- 表观遗传学 在表观遗传学中,表观遗传学是指表观遗传学.
背景情况:
- 新生儿糖尿病 (NDM) 是一种罕见的单一性疾病,在婴儿出生前六个月内引起高血糖症.
- 在生命早期的肠道微生物群失调和NDM易感性之间的关系尚未完全理解.
- 孕期糖尿病 (GDM) 可能通过诱导新生儿的美和肠道微生物群失生症来调解NDM病原体.
研究的目的:
- 审查饮食,肠道微生物群和表观遗传交叉对新生儿糖尿病中改变基因表达的影响.
- 阐明将GDM中的母亲饮食与肠道微生物群变化以及随后的NDM基因表达联系在一起的机制.
主要方法:
- 本综述综合了现有的实验性和表观基因组范围的关联研究.
- 它侧重于饮食,肠道微生物群组成和表观遗传修饰 (DNA甲基化) 之间的相互作用.
主要成果:
- GDM与新生儿肠道微生物群失生症有关.
- 表观遗传修饰,如带血和胎盘中的DNA甲基化变化,与GDM有关.
- 在GDM中,饮食因素可能会影响肠道微生物群,可能会影响与NDM相关的基因表达.
结论:
- 肠道微生物群失调,可能受到母亲的GDM和饮食的影响,可能在NDM病变发生过程中发挥作用.
- 表观遗传机制对于调解肠道微生物群,易感基因和新生儿免疫系统之间的相互作用至关重要.
- 需要进一步的研究来揭示在NDM发育过程中饮食,肠道微生物群和表观遗传学之间的确切机制.
相关概念视频
01:23Anatomy of the Intestines
72.6K
Although digestion of proteins, carbohydrates, and lipids may begin in the stomach, it is completed in the intestine. The absorption of nutrients, water, and electrolytes from food and drink also occurs in the intestine. The intestines can be divided into two structurally distinct organs—the small and large intestines.
Small Intestines
The small intestine is an ~7 meter-long tube with an inner diameter of just 2.5 cm. Since most nutrients are absorbed here, the inner lining of the...
Small Intestines
The small intestine is an ~7 meter-long tube with an inner diameter of just 2.5 cm. Since most nutrients are absorbed here, the inner lining of the...
72.6K
01:20Pathophysiology of Diabetes
1.0K
Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia. The four categories of diabetes are type 1 diabetes, type 2 diabetes, other specific types of diabetes, and gestational diabetes.
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
1.0K
01:22Diabetes Mellitus: Type 2 and Gestational
2.6K
Type 2 diabetes, characterized by insulin resistance, arises when the insulin receptors on cells lose responsiveness to insulin, diminishing the cell's capacity to take up glucose, resulting in elevated blood glucose levels. To receive a diagnosis of Type 2 diabetes, a series of blood glucose tests are necessary to assess whether the blood glucose falls within normal parameters. If the result is out of the normal range, a patient may be diagnosed as prediabetic or diabetic, depending on the...
2.6K
01:50What is Monogastric Digestion?
71.7K
The human body contains a monogastric digestive system. In a monogastric digestive system, the stomach only contains one chamber in which it digests food. Several other animal species also have monogastric digestive systems, including pigs, horses, dogs, and birds. This chapter, however, focuses on the human digestive system.
71.7K