ACE-I/D基因组调节了通过间隔式运动改善心肺功能和肌肉性能
Benedikt Gasser1, David Niederseer2, Walter O Frey3
1Departement für Bewegung und Sport, Universität Basel, CH-4052 Basel, Switzerland.
血管激素转化酶 (ACE) I/D基因型影响间歇训练如何影响肌肉性能和恢复. 与非载体相比,ACE I基因基因携带者在肌肉氧化和无氧功率方面表现出不同的反应.
科学领域:
- 运动生理学 运动生理学
- 人类遗传学 人类遗传学
- 运动科学 运动科学 运动科学
背景情况:
- 血管激素转化酶 (ACE) 插入/删除 (I/D) 多态性与心血管和骨肌肉适应运动有关.
- 训练反应的变化表明,像ACE基因型这样的遗传因素发挥了作用.
研究的目的:
- 调查ACE I/D基因型是否与对间隔训练反应的个体差异有关.
- 检查间歇训练对外围肌肉有氧和无氧性能,心血管功能和恢复的影响,考虑到ACE基因型.
主要方法:
- 九名健康受试者接受了为期八周的间歇训练,使用软机器人踏板装置.
- 测量包括运动期间的峰值有氧和无氧功率,肌肉氧化 (SmO2),血红蛋白度 (tHb),血液乳酸和心血管参数 (心率,血压).
- 用聚合酶链反应进行了ACE I/D多态的基因定型.
主要成果:
- 间歇训练显著改善了肌肉工作/力量,心脏输出和肌肉氧气脱.
- ACE I-基因基因对肌肉代谢和氧和的运动诱导变化产生影响,I-基因基因基因基因携带者在上坡运动期间显示出更有利的氧气缺乏变化.
- 在ACE I等位基因携带者中,有氧性峰值功率增加,但非携带者没有,而无氧性能的改善在基因型之间有所不同.
- 康复期间的心血管反应和心率和葡萄糖的训练不变差异与ACE基因型有关.
结论:
- ACE I/D基因型调节了对间隔训练的适应性反应,特别是关于骨肌肉 perfusion 和有氧新陈代谢.
- 虽然非载体可以改善有氧肌肉代谢,但反应程度取决于工作.
- 与ACE基因型相关的遗传因素对心血管功能产生重大影响,间隔训练可能无法完全克服.
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