多个per-和多基基物质暴露在全静电负荷上的综合效应,使用贝叶斯核机器回归
Tahir Bashir1,2, Emmanuel Obeng-Gyasi1,2
1Department of Built Environment, North Carolina A&T State University, Greensboro, NC 27411, USA.
对某些超和多基基物质 (PFAS) 的联合暴露显著增加了静电负荷,这是慢性压力的标志物. 了解这些累积的PFAS影响对于公共卫生和疾病预防战略至关重要.
科学领域:
- 环境健康科学 环境健康科学
- 毒理学 毒理学 毒理学
- 公共卫生 公共卫生
背景情况:
- 和多基基物质 (PFAS) 是广泛存在的环境污染物.
- 长期暴露于PFAS与各种不良健康结果有关.
- 静态负荷作为累积压力和疾病风险的生物标志物.
研究的目的:
- 为了研究多个PFAS对全静电负荷的综合影响.
- 为了确定特定的PFAS和与增加的全静电负荷相关的暴露模式.
- 为减轻与PFAS相关的健康风险提供公共卫生战略的信息.
主要方法:
- 使用了国家健康和营养检查调查 (NHANES) 数据 (2007-2014).
- 采用贝叶斯核机器回归 (BKMR) 来分析六个PFAS与全静电负载之间的关系.
- 使用单变量,双变量和多变量模型检查PFAS个体和组合暴露.
主要成果:
- 对PFDE,PFNA和PFUA的联合暴露显示出在全静态负荷 (二进制模型) 中显著的积极趋势.
- PFDE,PFOS和PFNA在全静态负荷 (连续模型) 中显示出显著的积极趋势.
- 这些发现突显了PFAS累积暴露对慢性压力标志物的影响.
结论:
- 累积暴露于特定的PFAS与增加的全静电负荷有关.
- 在评估健康风险时,公共卫生工作应考虑联合PFAS暴露.
- 需要有效的策略来最大限度地减少对有害 PFAS 化学品的暴露.
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