在ICR小鼠中碎片化聚烯微塑料的毒性和生物分布
Sijoon Lee1, Dongseon Kim1,2, Kyung-Ku Kang1
1Preclinical Research Center, Daegu-Gyeongbuk Medical Innovation Foundation, Daegu 41061, Republic of Korea.
International journal of molecular sciences
|May 27, 2023
概括
聚烯 (PP) 微塑料在小鼠中没有引起显著的毒性. 大多数微塑料在24小时内被消除,这表明哺乳动物的短期积累很低.
科学领域:
- 环境科学 环境科学
- 毒理学 毒理学 毒理学
- 材料科学 材料科学 材料科学
背景情况:
- 聚烯 (PP) 广泛使用,导致人类接触PP微塑料的增加.
- 评估PP微塑料的毒理影响,生物分布和积累至关重要.
研究的目的:
- 评估PP微塑料在哺乳动物中的短期毒性和生物分布.
- 确定PP微塑料的近似致命剂量和没有观察到不良影响水平 (NOAEL).
主要方法:
- 将两种尺寸的PP微塑料 (5微米和10-50微米) 给ICR小鼠.
- 毒理学评估,包括体重和病理学检查.
- 在体内生物分布追踪使用标有素5.5碳酸 (Cy5.5-COOH) 的PP微塑料.
主要成果:
- 在用PP微塑料治疗的小鼠中没有观察到显著的毒理变化.
- 估计的致命剂量和NOAEL被确定为≥2000 mg/kg.
- 大多数口服的PP微塑料在胃肠道中被发现,并在24小时内排出.
结论:
- 在ICR小鼠中,PP微塑料具有较低的短期毒性.
- 主要排泄的途径是通过胃肠道.
- 这项研究提供了关于哺乳动物中PP微塑料有限的短期积累和分布的见解.
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