在COVID-19中的炎症反应取决于疾病的严重程度和疫苗接种状态
Felicia Trofin1,2, Eduard Vasile Nastase2,3, Manuel Florin Roșu2,4
1Microbiology Department, University of Medicine and Pharmacy "Grigore T. Popa", 700115 Iasi, Romania.
International journal of molecular sciences
|May 27, 2023
概括
炎症标志物如IL-6,CRP,D-二聚体和费里丁随着COVID-19的严重程度而增加. 未接种疫苗的患者的结果更差,D-二次体最好预测严重疾病,而LDH则表明病毒变种.
科学领域:
- * 传染病的生物化学和免疫学.
- * 临床病理和疾病严重程度标志物.
背景情况:
- *COVID-19呈现出不同的临床严重程度,受疫苗接种状态和病毒变异等因素的影响.
- * 炎症标志物对于评估疾病进展和患者的结果至关重要.
研究的目的:
- * 在COVID-19患者中分析关键炎症标记物 (IL-6,CRP,D-二次体,LDH,费里丁,公素) 的血清度.
- *将这些标志物与疾病严重程度,疫苗接种情况,性别和病毒变异相关联.
- * 评估D-二聚和LDH对严重的COVID-19和病毒变异的预测值.
主要方法:
- *对137名连续COVID-19患者进行前性队列研究.
- *分为四组:轻度,中度,严重和危急的疾病形式.
- *血清生物标记分析和与临床数据,疫苗接种状态和病毒变异的相关性.
主要成果:
- *所有测试的炎症标志物 (IL-6,CRP,D-二次体,LDH,费里丁) 随着COVID-19的严重程度而增加.
- *根据疫苗接种状态,性别和病毒变体 (LDH) 观察到标志物度的显著差异.
- * D-二次体显示了严重COVID-19的最高预测值;LDH预测了病毒变异.
- * 感染Omicron的患者的炎症标志物较低,未接种疫苗的患者的炎症标志物一般较高.
结论:
- *炎症标志物与COVID-19的临床严重程度有显著的关联.
- *疫苗接种状态会影响疾病的严重程度和结果,未接种疫苗的患者会出现更严重的形式.
- * D-二聚体和LDH分别是疾病严重程度和病毒变异的有价值的预测生物标志物.
关键词:
在 COVID-19 疫情中,在CRP中使用CRP.在IL-6的研究中,IL-6被认为是IL-6的基因.在 LDH 和 LDH 之间.这就是SARS-CoV-2病毒.费里丁是一种铁素.严重程度的严重程度.更多相关视频
07:36Contact-Free Co-Culture Model for the Study of Innate Immune Cell Activation During Respiratory Virus Infection
Published on: February 28, 2021
2.9K
07:48Intravenous Endotoxin Challenge in Healthy Humans: An Experimental Platform to Investigate and Modulate Systemic Inflammation
Published on: May 16, 2016
11.7K
相关概念视频
Immune Response Against Viral Pathogens
837
The immune system's response to viral infections is a complex and coordinated process involving natural killer (NK) cells, T cell-mediated responses, and antibody-mediated responses.
NK Cells
NK cells are a crucial part of our innate immune system, acting as the first line of defense against viral infections. These cells can recognize and kill infected cells without prior exposure to the virus, effectively slowing down the spread of infection. Additionally, NK cells produce proinflammatory...
NK Cells
NK cells are a crucial part of our innate immune system, acting as the first line of defense against viral infections. These cells can recognize and kill infected cells without prior exposure to the virus, effectively slowing down the spread of infection. Additionally, NK cells produce proinflammatory...
837
Vaccinations
44.9K
Overview
44.9K
Inflammatory Response I: Vascular and Cellular
11.5K
The inflammatory response is the body's defense against infection, injury, or irritation from bacteria, trauma, toxins, or heat. Inflammation helps locate and destroy pathogens and remove damaged tissue elements to heal the body. During this initial phase, fluid, blood products, and nutrients migrate to the injured area, resulting in redness, heat, swelling, ache, and loss of function. Moreover, signs of systemic inflammation include fever, increased WBC count, malaise, anorexia, nausea,...
11.5K
Inflammatory Response
2.2K
An inflammatory response is a localized, nonspecific immune reaction that occurs when a tissue is injured. It is characterized by redness, swelling, heat, and pain, which are commonly called the cardinal signs and symptoms of inflammation. Inflammation can sometimes result in a loss of function.
Inflammation can be triggered by various stimuli, such as impact, abrasion, chemical irritation, infections, and extreme hot or cold temperatures. These can damage cells and connective tissue fibers,...
Inflammation can be triggered by various stimuli, such as impact, abrasion, chemical irritation, infections, and extreme hot or cold temperatures. These can damage cells and connective tissue fibers,...
2.2K
Factors Affecting the Risk of Infection
12.1K
The hosts' susceptibility to infection depends on several factors. The integrity of the skin and mucous membranes helps protect the body against microbial attacks. When the skin is altered, the chance of infection, limb loss, and even death increases.
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
12.1K
Inflammation
54.0K
Overview
54.0K
