二次性骨质疏松症:一个仍然被忽视的疾病
Vittoria Favero1, Cristina Eller-Vainicher2, Iacopo Chiodini1,3
1Department of Biotechnology and Translational Medicine, University of Milan, 20122 Milan, Italy.
International journal of molecular sciences
|May 27, 2023
概括
二次性骨质疏松症是由于其他疾病引起的骨质损失. 了解这些原因是有效管理这种骨病的关键.
科学领域:
- 内分泌学和新陈代谢学
- 骨生物学 骨生物学 骨生物学
- 老年医学 老年医学
背景情况:
- 二次性骨质疏松症的特点是由于特定的,可识别的临床疾病引起的骨质损失.
- 这与原发性骨质疏松症形成鲜明对比,原发性骨质疏松症有多因素的原因,没有单一可识别的潜在疾病.
- 精确的定义强调了确定针对性治疗的潜在病因的重要性.
研究的目的:
- 为了定义二级骨质疏松症.
- 概述与二次骨质疏松症相关的各种临床疾病.
主要方法:
- 审查现有的医学文献.
- 对二次性骨质疏松症的诊断标准的分析.
主要成果:
- 建立了对二次性骨质疏松症的明确定义.
- 列出了各种相关的临床疾病,包括内分泌,胃肠道和类风湿病.
结论:
- 二次性骨质疏松症是一个重要的临床实体,需要承认其多样化的病因.
- 准确的诊断取决于确定潜在的致病性疾病,以便针对性治疗.
相关概念视频
Bone Disorders
3.7K
Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
3.7K
Bone Remodeling
38.4K
Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
38.4K
Osteoclasts in Bone Remodeling
3.0K
Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during...
3.0K
What is the Skeletal System?
53.0K
Overview
53.0K
The Functions of the Skeletal System
4.0K
The most apparent functions of the skeletal system are support, protection, and movement. However, bone tissue also performs several other critical metabolic functions. For one, the bone matrix acts as a reservoir for a number of minerals important to the functioning of the body, especially calcium and phosphorus. These minerals, present in the bone tissue, can be released back into the bloodstream when required. Calcium ions, for example, are essential for muscle contractions and controlling...
4.0K
Role of Vitamins in Maintaining Bone Health
3.5K
The growth and maintenance of bone are regulated by a combination of nutritional factors, including vitamins, such as vitamin A, B12, C, D, and K.
Vitamin A
Vitamin A is involved in the process of bone remodeling. Retinoic acid, the active metabolite of Vitamin A, has nuclear receptors in osteoblasts and osteoclasts, which are involved in bone remodeling.
Vitamin B12
Vitamin B12 acts as a cofactor during the formation of osteoblast-related proteins, such as osteocalcin. Vitamin B12 plays a role...
Vitamin A
Vitamin A is involved in the process of bone remodeling. Retinoic acid, the active metabolite of Vitamin A, has nuclear receptors in osteoblasts and osteoclasts, which are involved in bone remodeling.
Vitamin B12
Vitamin B12 acts as a cofactor during the formation of osteoblast-related proteins, such as osteocalcin. Vitamin B12 plays a role...
3.5K


