在西班牙通过定期基因组测序加强SARS-CoV-2监测:RELECOV网络
Sonia Vázquez-Morón1,2, María Iglesias-Caballero1, José Antonio Lepe3
1Respiratory Viruses and Influenza Unit, National Centre for Microbiology, Instituto de Salud Carlos III, 28222 Majadahonda, Spain.
International journal of molecular sciences
|May 27, 2023
概括
西班牙RELECOV网络通过将病毒序列共享增加36%,增强了SARS-CoV-2基因组监测. 这一举措改善了病毒检测,分析和评估,加强了国家公共卫生监测能力.
科学领域:
- 病毒学 病毒学
- 基因组学就是基因组学.
- 公共卫生 公共卫生
背景情况:
- 数以百万计的SARS-CoV-2全基因组序列存在,但强大的监测需要高质量的数据和系统.
- 西班牙冠状病毒实验室网络 (RELECOV) 成立,以加速在全国范围内检测,分析和评估SARS-CoV-2.
- 一个欧洲疾病预防控制中心 (ECDC) -HERA-化器行动部分资助RELECOV.
研究的目的:
- 通过SARS-CoV-2测序质量控制评估 (QCA) 来评估RELECOV网络的技术能力.
- 用48,578个病毒基因组的基因组数据来监测SARS-CoV-2.
- 评估RELECOV网络行动对病毒序列共享和基因组监测的影响.
主要方法:
- 开发和实施SARS-CoV-2测序质量控制评估 (QCA).
- 分析了48578个SARS-CoV-2病毒基因组.
- 遗传学分析以将基因组数据与变种群相关联.
- 鉴定定义血统/亚血统的突变,用于变种追踪.
主要成果:
- 该QCA显示,与变体分配相比,谱系分配的命中率较低.
- 在RELECOV网络行动中,病毒序列共享率增加了36%.
- 对于Delta和Omicron变种,已经确定了不同的突变特征.
- 遗传学分析证实了变种群,并建立了一个强大的参考树.
结论:
- 在西班牙,RELECOV网络显著改善了SARS-CoV-2基因组监测.
- 该网络为有效的病毒基因组监测和表征提供并评估了基因组工具.
- RELECOV加强知识传播,并促进对SARS-CoV-2的强有力的基因组监测.
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