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基于结构的设计强大的皮相仿抑制剂共价向SARS-CoV-2帕帕因样蛋白酶

Qian Wang1,2, Guofeng Chen2,3, Jian He2,3

  • 1School of Chinese Materia Medica, Nanjing University of Chinese Medicine, Nanjing 210023, China.

International journal of molecular sciences
|May 27, 2023
PubMed
概括

研究人员设计了针对SARS-CoV-2的帕帕因类蛋白酶 (PLpro) 的新型皮胺抑制剂. 这些抑制剂在细胞检测中显示出强大的抗病毒活性,并证实了共价结合,提供了针对SARS-CoV-2的新疗法策略.

关键词:
这就是SARS-CoV-2病毒.同晶体结构的共同晶体结构.作为一种共价抑制剂.在体外测定试验.帕帕因类蛋白酶是一种类似帕帕因的蛋白酶.

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