牙髓干细胞用于唾液腺再生 - 我们今天在哪里?
David Muallah1, Jan Matschke2, Matthias Kappler3
1Department of Oral and Maxillofacial Surgery, University Hospital Hamburg-Eppendorf, Martinistraße 52, 20251 Hamburg, Germany.
International journal of molecular sciences
|May 27, 2023
概括
牙髓干细胞为治疗唾液腺功能低下引起的口腔干燥 (xerostomia) 提供了一种有前途的再生方法. 它们的差异化和免疫调节潜力可能会彻底改变口治疗,尽管临床研究尚未完成.
科学领域:
- 再生医学是一种再生医学.
- 干细胞生物学 干细胞生物学
- 口腔医学是指口腔医学.
背景情况:
- Xerostomia (口腔干燥) 显著损害生活质量,由于液腺功能下降,由于各种原因,如瘤,辐射或自身免疫性疾病.
- 目前的治疗方法,包括唾液替代品和寄生共感药物,对异口症的疗效有限.
- 再生医学为包括唾液腺在内的受损组织提供了一个新的治疗途径.
研究的目的:
- 审查目前在唾液腺再生中利用牙髓干细胞 (DPSCs) 的策略.
- 探索DPSCs在治疗异口症和相关疾病方面的潜力.
主要方法:
- 对研究的文献综述,研究了用于组织工程和再生医学的牙纸干细胞.
- 对DPSC属性的分析,包括分化能力和免疫调节效应.
- 检查目前的治疗方法为异口症和他们的局限性.
主要成果:
- 牙髓干细胞是成年干细胞,很容易从拔出的牙中获取.
- DPSCs具有将其分化为各种细胞类型,并从所有三个生殖层中形成组织的能力.
- 这些细胞表现出免疫调节效应,抑制前炎性淋巴细胞通路,使它们适合自身免疫和炎症性疾病.
结论:
- 牙纸干细胞对唾液腺组织再生和异口症的治疗具有重大前景.
- DPSCs的独特属性,包括它们的分化潜力和免疫调节性质,使它们成为解决异口症的可行工具.
- 进一步的临床研究是必要的,以验证DPSCs在治疗异口症的治疗疗效.
关键词:
据了解,DPSC是该公司的总监.斯约格伦综合征是什么意思牙髓干细胞是牙髓的干细胞.不同化的差异化差异化.再生医学是一种再生医学.唾液腺体 唾液腺体 唾液腺体组织工程是组织工程.克塞罗斯托米亚 (Xerostomia) 是一种更多相关视频
03:45Author Spotlight: Advancing Tissue Regeneration and Disease Modeling with Dental Pulp Stem Cells
Published on: May 5, 2023
2.3K
14:52Isolation, Characterization and Comparative Differentiation of Human Dental Pulp Stem Cells Derived from Permanent Teeth by Using Two Different Methods
Published on: November 24, 2012
26.5K
相关概念视频
Stem Cell Therapy for Tissue Regeneration
4.1K
Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell...
Types of Stem Cells used in Stem Cell Therapy
The two main cell...
4.1K
Source And Potency Of Stem Cells
5.0K
Stem cells are undifferentiated cells with extensive self-renewal properties that help them maintain their population during the fetal and adult stages of life. They can specialize in all cell types of the human body. However, their differential potential may vary and can be classified into five types. Stem cells can be (1) Totipotent, (2) Pluripotent, (3) Multipotent, (4) Oligopotent, and (5) Unipotent. Each stem cell has a specific origin; the fertilized egg or zygote is a totipotent cell and...
5.0K
Mesenchymal Stem Cells
4.8K
Mesenchymal stem cells (MSCs) are adult stem cells that can differentiate into most connective tissue cell types, except for hematopoietic cells, depending upon the source of MSCs. For example, bone-marrow-derived MSCs (BM-MSCs) can differentiate into osteocytes, hepatocytes, and pancreatic and neuronal cells. MSCs can be isolated from various sources such as bone marrow, placenta, adipose tissue, teeth, and Wharton’s jelly, a gelatinous substance in the umbilical cord. The ease of their...
4.8K
Stem Cell Culture
5.2K
Stem cell research aims to find ways to use stem cells to regenerate and repair cellular damage. Over time, most adult cells undergo the wear and tear of aging and lose their ability to divide and repair themselves. Stem cells do not display a particular morphology or function. Adult stem cells, which exist as a small subset of cells in most tissues, keep dividing and can differentiate into a number of specialized cells generally formed by that tissue. These cells enable the body to renew and...
5.2K
