通过与冷物理等离子体结合,增强化疗对尤文肉瘤细胞的影响
Andreas Nitsch1, Sara Qarqash1, Sarah Römer2
1Center for Orthopedics, Trauma Surgery and Rehabilitation Medicine, University Medicine Greifswald, Ferdinand-Sauerbruch-Straße, 17475 Greifswald, Germany.
International journal of molecular sciences
|May 27, 2023
概括
结合化疗的冷物理血 (CPP) 显著增强了对尤文肉瘤 (ES) 的治疗效果. 这种创新方法可以促进癌细胞的死亡,降低癌细胞的活力,为这种侵袭性儿童癌症提供了一个有前途的新策略.
科学领域:
- 在瘤学瘤学.
- 生物物理学的生物物理.
- 癌症生物学 癌症生物学
背景情况:
- 尤文肉瘤 (ES) 是一种具有挑战性的治疗结果的侵袭性儿科肌肉骨癌.
- 化疗耐药性和副作用限制了当前ES治疗的疗效.
- 冷物理等离子体 (CPP) 产生反应性氧和物种,提供潜在的抗癌机制.
研究的目的:
- 研究CPP和标准化疗对ES细胞的协同作用.
- 评估CPP作为辅助疗法的潜力,以提高化疗疗效.
- 评估CPP和化疗组合对ES细胞生长,活力和亡的影响.
主要方法:
- 在RD-ES和A673细胞系中确定了多克索鲁比辛和温克里斯的IC20和IC50值.
- 单独和结合使用ES细胞系的单个化疗药物和CPP.
- 研究了对细胞生长,细胞活力和亡过程的影响.
主要成果:
- 单次CPP治疗以剂量依赖的方式抑制ES细胞生长.
- 联合CPP和细胞静止治疗显著抑制细胞生长和降低活力.
- 与单独使用CPP或化疗相比,组合疗法导致亡率更高.
结论:
- CPP增强了常见的化疗剂对ES细胞的细胞毒性作用.
- 临床前体外数据表明,CPP可以提高标准ES治疗的疗效.
- 作为ES治疗中临床应用的支持性抗瘤疗法,CPP显示出前景.
相关概念视频
Cancer Therapies
7.8K
Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
7.8K
Combination Therapies and Personalized Medicine
5.0K
Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
5.0K
Tumor Immunotherapy
577
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
577


