含有植物提取物的基托桑膜:制备,表征和抗菌性质
Luiza Madalina Gradinaru1, Mihaela Barbalata-Mandru1, Alin Alexandru Enache2
1"Petru Poni" Institute of Macromolecular Chemistry, 41A Grigore Ghica Voda Alley, 700487 Iasi, Romania.
International journal of molecular sciences
|May 27, 2023
概括
这项研究开发了用 (S. officinalis) 和圣约翰草 (H. perforatum) 提取物制成的基托桑膜,用于抗菌性伤口包裹. 这些新型膜显示出有希望的物理化学和抗菌性质,用于伤口愈合应用.
科学领域:
- 生物材料科学 生物材料科学
- 聚合物工程 聚合物工程
- 药理学 药理学是指药理学的学科.
背景情况:
- 传统药物提取物提供抗微生物的好处.
- 聚合物支架为伤口带提供结构支持.
- 结合这些方法可以创建先进的伤口护理材料.
研究的目的:
- 开发基于酸盐的膜,其中包含 (S. officinalis) 和圣约翰草 (H. perforatum) 提取物.
- 评估这些新型膜作为伤口包裹的物理化学特性和抗菌疗效.
主要方法:
- 用植物提取物制造基托基膜.
- 使用扫描电子显微镜 (SEM) 进行形态分析.
- 通过富里埃变换红外光谱法 (FTIR) 进行化学结构表征.
- 在化介质中评估液体吸附能力和材料完整性.
- 使用Kirby-Bauer磁盘扩散方法对阳性和阴性细菌进行抗菌活性测试.
主要成果:
- 含有S. officinalis和H. perforatum提取物的奇托桑膜显示了增强的吸附能力.
- 膜在化介质,特别是PBS中保持结构完整14天.
- 添加植物提取物显著改善了对测试细菌的抗微生物特性.
- 对于格拉姆阳性 (S. aureus,MRSA) 和格拉姆阴性 (E. coli,P. aeruginosa) 微生物均观察到增强的抗菌活性.
结论:
- 开发出来的基托基膜具有有利的物理化学和抗菌性质.
- 这些膜显示出作为先进的伤口料材料的巨大潜力.
- 奇托,S. officinalis和H. perforatum提取物的组合为新型抗微生物伤口护理提供了一个有希望的策略.
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