桑布库斯 (Sambucus ebulus) 果实调节人类的炎症和补充系统活动
Yoana Kiselova-Kaneva1, Milka Nashar1, Bogdan Roussev1
1Department of Biochemistry, Molecular Medicine and Nutrigenomics, Faculty of Pharmacy, Medical University "Prof. Dr. Paraskev Stoyanov", 9002 Varna, Bulgaria.
International journal of molecular sciences
|May 27, 2023
概括
在健康的成年人中, (Sambucus ebulus) 水果输液减少了炎症标志物和补充活性. 这项研究为其免疫调节效应提供了第一个人类证据.
科学领域:
- 免疫学 免疫学 免疫学
- 药理学 药理学是指药理学的学科.
- 人类营养人类营养
背景情况:
- 桑布库斯埃布卢斯 (Sambucus ebulus,SE) 的水果传统上用于免疫支持和胃肠道健康.
- 对SE对人类免疫反应机制的影响缺乏科学证据.
- 这项研究研究了SE水果输液在健康个体中的免疫调节潜力.
研究的目的:
- 在健康的志愿者中评估 Sambucus ebulus 水果输液的免疫调节作用.
- 在4周的干预后,评估免疫标记和炎症状况的变化.
- 为了确定对观察到的效应负责的关键安托西亚宁.
主要方法:
- 53名健康的志愿者参与了为期4周的SE水果输液干预.
- 血液样本被分析为完整血清,总蛋白质和炎症标志物 (IL-1β,IL-6,TNFα,hs-CRP,C3,C4,IL-8).
- 在SE样品中使用UPLC-ESI-MS/MS.进行了安托西亚宁分析.
主要成果:
- 研究人员观察到,瘤坏死因子α (TNFα),瘤坏死因子α (TNFα),瘤坏死因子α (TNFα),瘤坏死因子α (TNFα),瘤坏死因子α (TNFα),瘤坏死因子α (TNFα),瘤坏死因子α (TNFα),瘤坏死因因子α (TNFα),瘤坏死因子α (TNFα),瘤坏死因子α (TNFα),瘤坏死因子α (TNFα),瘤坏死因子α (TNFα),瘤坏死因子α (TNFα),瘤坏死因子α (TNFα),瘤坏死因子α),瘤坏死因子α (TNFα),瘤坏死因子α (TNFα),瘤坏死因子α (TNFα),瘤坏死因子α (TNFα),瘤坏死因子α (TNFα) 的水平显著降低.
- 在男性和女性中都注意到炎症标志物和补充蛋白的具体减少.
- 血红蛋白和血红素水平在整体组和女性中略有下降.
结论:
- 桑布库斯 ( Sambucus ebulus) 水果的摄入量在健康人群中显示出显著的免疫调节活性.
- 这种干预导致促进炎症状态和补充系统活动的下降.
- 富含丁-3-O-银酸等抗素的SE果实显示出作为天然免疫调节剂的潜力.
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