SERPINE1 mRNA结合蛋白1与缺血性中风风险有关:对SERBP1SNP进行全面的分子遗传和生物信息学分析
Irina Shilenok1,2, Ksenia Kobzeva1, Tatiana Stetskaya3
1Laboratory of Genomic Research, Research Institute for Genetic and Molecular Epidemiology, Kursk State Medical University, 305041 Kursk, Russia.
International journal of molecular sciences
|May 27, 2023
概括
SERBP1基因中的单核酸多态 (SNP) 与缺血性中风 (IS) 风险增加和血液凝固时间改变有关. 这些SERBP1基因变异可能成为IS的新型遗传标记物.
科学领域:
- 遗传学 遗传学 是一个
- 神经学 神经学
- 分子生物学分子生物学
背景情况:
- 众所周知,SERBP1基因是调节SERPINE1mRNA稳定性和孕激素信号的.
- 最近的发现突出了SERBP1的陪伴者类属性.
- 缺血性中风 (IS) 风险和临床表现的遗传基础需要进一步调查.
研究的目的:
- 调查SERBP1基因中单核酸多态 (SNPs) 与缺血性中风 (IS) 风险之间的关联.
- 探索SERBP1SNP与IS临床表现之间的关系,包括凝血时间.
主要方法:
- 在2060名俄罗斯受试者 (869名IS患者,1191名对照者) 中,对5种常见的SERBP1SNP (rs4655707,rs1058074,rs12561767,rs12566098,rs6702742) 进行基因定型.
- 使用基于探针的PCR进行DNA样本基因定型的分析.
- 统计分析以评估SNP与IS风险和激活部分血栓形成时间 (aPTT) 的关联.
主要成果:
- SNP rs12566098 (基因基因基因C) 显示与IS风险增加有显著的关联 (p=0.001),受生活方式因素的影响.
- SNP rs1058074 (C基因基因) 与更高的IS风险有关,特别是在女性和非吸烟者,以及体力活动低,水果/蔬菜摄入量低,BMI ≥25.
- 五个SERBP1SNP (rs1058074,rs12561767,rs12566098,rs6702742,rs4655707) 与激活的部分血栓形成时间缩短有关.
结论:
- 现在,SERBP1 SNPs成为潜在的新型遗传标记物,用于缺血性中风风险.
- 特定的SERBP1多态可能会影响IS易感性和临床特征,包括凝血参数.
- 需要进一步的研究来验证SERBP1基因变异与IS之间的联系.
关键词:
在SERBP1中,塞尔皮因1 mRNA结合蛋白 1在SNP中,SNP是SNP.激活的部分血栓塑时间.身体质量指数 (BMI) 是指身体质量指数.陪伴者是指一个陪伴者.基因与环境的相互作用耐热的 模糊的 模糊的英雄的英雄的英雄的英雄的英雄缺血性中风 中风更多相关视频
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