布蒂罗菲林:在癌症中保护性T细胞免疫力的动态调节剂
Rinkee Kumari1, Elaheh Sadat Hosseini1,2, Kristen E Warrington1
1Medical Immunology, Rutgers Cancer Institute of New Jersey, New Brunswick, NJ 08901, USA.
International journal of molecular sciences
|May 27, 2023
概括
丁氨基胺 (BTN) 和丁氨基胺类分子 (BTNL) 是固体瘤中强大的免疫抑制剂. 了解它们的生物学,特别是BTN3A1,为癌症免疫疗法提供了新的点,可以增强目前的治疗方法.
科学领域:
- 免疫学 免疫学 免疫学
- 在瘤学瘤学.
- 分子生物学分子生物学
背景情况:
- 目前的免疫疗法对固体上皮质恶性瘤的疗效有限.
- 丁胺 (BTN) 和丁胺类分子 (BTNL) 被确定为瘤微环境中的强有力的免疫抑制剂.
- 这些分子在细胞表面上动态结合,调节它们的生物功能.
研究的目的:
- 探索BTN和BTNL分子在癌症中的生物学.
- 专注于BTN3A1在T细胞活性和免疫抑制中的作用.
- 讨论BTN/BTNL作为瘤学新型免疫治疗点的潜力.
主要方法:
- 对BTN和BTNL生物学当前文献的综述.
- 分析BTN3A1在T细胞激活和抑制中的作用.
- 讨论与现有的癌症免疫疗法的潜在协同效应.
主要成果:
- BTN和BTNL分子具有免疫抑制功能,特别是在固体瘤中.
- BTN3A1的动态相互作用影响了阿尔法-βT细胞抑制和马-三角形T细胞激活.
- 这些分子代表了癌症免疫疗法开发的有希望的目标.
结论:
- 对BTN和BTNL生物学进行进一步的研究对于了解它们在癌症中的作用至关重要.
- 针对BTN/BTNL分子,特别是BTN3A1,可能会导致新的免疫治疗策略.
- 基于BTN/BTNL的疗法可能与当前的免疫调节剂协同作用,以改善癌症治疗结果.
相关概念视频
T Cell Activation and Clonal Selection
845
T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
Naive T cells that have not yet encountered an antigen express two primary CD...
Naive T cells that have not yet encountered an antigen express two primary CD...
845
T Cell Types and Functions
1.1K
When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
1.1K
Tumor Immunotherapy
577
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
577
Cytotoxic T Cells-mediated Immune Response
1.0K
Cytotoxic T cells are a vital component of the immune system. They have the remarkable ability to identify and target antigens on infected or abnormal cells. These antigens often originate from intracellular pathogens such as viruses or abnormal proteins cancer cells produce.
Immunological surveillance is the ability of immune cells to monitor and eliminate infected cells with intracellular pathogens, neoplastically transformed cells, and cells with non-self antigens. Cytotoxic T cells and NK...
Immunological surveillance is the ability of immune cells to monitor and eliminate infected cells with intracellular pathogens, neoplastically transformed cells, and cells with non-self antigens. Cytotoxic T cells and NK...
1.0K
Receptor Downregulation in MVBs
2.1K
Multivesicular bodies (MVBs) are mature endosomes that sort ubiquitinated proteins and then fuse with lysosomes to degrade the sorted proteins. Epidermal growth factor (EGF) and its receptor (EGFR) form a complex that can be internalized through endocytosis, sorted into an MVB, and later degraded.
The EGFR can initiate signaling pathways that lead to cell proliferation, migration, and differentiation. Overexpression of EGFR stimulates cells to proliferate. Excessive EGFR...
The EGFR can initiate signaling pathways that lead to cell proliferation, migration, and differentiation. Overexpression of EGFR stimulates cells to proliferate. Excessive EGFR...
2.1K
mTOR Signaling and Cancer Progression
3.8K
The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
The mTOR pathway or the...
3.8K


